4-AMINO-2,6-DIBROMOPHENOL Property

Melting point:

195-196 °C(lit.)

Boiling point:

295.6±40.0 °C(Predicted)

Density 

2.0444 (rough estimate)

refractive index 

1.6400 (estimate)

storage temp. 

2-8°C(protect from light)

pka

7.17±0.23(Predicted)

BRN 

2803732

CAS DataBase Reference

609-21-2(CAS DataBase Reference)

EPA Substance Registry System

Phenol, 4-amino-2,6-dibromo- (609-21-2)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29222900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

4-AMINO-2,6-DIBROMOPHENOL Chemical Properties,Usage,Production

Chemical Properties

beige to pale brown crystalline powder

Synthesis

The synthesis of 4-amino-2,6-dibromophenol is as follows:4-Nitro-2,6-dibromophenol (2.97g, 10mmol) was dissolved in ethanol (15ml) and water (3ml), and acetic acid (1ml) was added. Then heat and stir to raise the temperature to 80°C, and add iron powder (1.68g, 30mmol) in batches. After the addition is complete, the reaction solution is kept warm for 30 minutes, heating is stopped, filtered while hot, the filtrate is concentrated under reduced pressure, then ethyl acetate and water are added to the concentrated residue to extract, the organic phases are combined and dried, filtered, and the solvent is removed under reduced pressure. The residue was finally separated by column chromatography (ethyl acetate/petroleum ether=1/3) to obtain 4-amino-2,6-dibromophenol (2.52g, 94.4% yield).