ChemicalBook > CAS DataBase List > Compstatin

Compstatin

Product Name: Compstatin
CAS No.: 206645-99-0
Chemical Name: Compstatin
Synonyms: Compstatin;Compstatin，ICVVQDWGHHRCT;Compstatin,ICVVQDWGHHRCT, >98%;Complement System,Inhibitor,Compstatin,inhibit;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond);Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond);L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid
CBNumber: CB81073593
Molecular Formula: C66H99N23O17S2
Formula Weight: 1550.77
MOL File: 206645-99-0.mol

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Compstatin Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 4.00±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Soluble to 2 mg/ml in sterile water
Sequence: H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2(Disulfide bridge: Cys2-Cys11)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2585
Product name: Compstatin
Packaging: 1
Price: $235
Updated: 2021/12/16

Usbiological

Product number: 255025
Product name: Compstatin
Packaging: 1mg
Price: $538
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC109863
Product name: Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)
Packaging: 1mg
Price: $410
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007963
Product name: COMPSTATIN
Purity: 95.00%
Packaging: 5MG
Price: $499.65
Updated: 2021/12/16

ChemScene

Product number: CS-7604
Product name: Compstatin
Packaging: 5mg
Price: $270
Updated: 2021/12/16

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Compstatin Chemical Properties,Usage,Production

Uses

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].

in vivo

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures^[1].
Compstatin is stable in baboon plasma for more than 24 h^[1].
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group^[2].

Animal Model:	Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg^[1].
Dosage:	50, 25 mg/kg 60 min after heparin and 2 min before protamine.
Administration:	A bolus injection.
Result:	Completely inhibited complement activation induced by heparin–protamine complexes.

storage

Store at -20°C

References

[1] Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21. DOI:10.1006/clim.2000.4903
[2] Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65. DOI:10.1034/j.1399-3089.1999.00007.x
[3] Bert J C Janssen, et al. Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem. 2007 Oct 5;282(40):29241-7. DOI:10.1074/jbc.M704587200
[4] A Sahu, et al. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 1996 Jul 15;157(2):884-91. PMID:8752942

Compstatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Compstatin Suppliers

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View Lastest Price from Compstatin manufacturers

Career Henan Chemical Co

Product: Compstatin 206645-99-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

206645-99-0, CompstatinRelated Search:

Compstatin

H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2

Compstatin

H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond)

Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)

Compstatin,ICVVQDWGHHRCT, >98%

L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide

Compstatin，ICVVQDWGHHRCT

Complement System,Inhibitor,Compstatin,inhibit

2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid

206645-99-0

C66H99N23O17S2