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BIM189

Product Name
BIM189
CAS No.
142062-55-3
Chemical Name
BIM189
Synonyms
BIM189;L-Phenylalaninamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-4-chloro-
CBNumber
CB81073689
Molecular Formula
C56H73ClN14O10
Formula Weight
1137.72
MOL File
142062-55-3.mol
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BIM189 Property

Boiling point:
1600.4±65.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 2 mg/ml in 20% acetonitrile
form 
solid
pka
13.12±0.46(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
254760
Product name
BIM 189
Packaging
1mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0004453
Product name
BIM 189
Purity
95.00%
Packaging
10MG
Price
$721.88
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0004453
Product name
BIM 189
Purity
95.00%
Packaging
100MG
Price
$1732.5
Updated
2021/12/16
ApexBio Technology
Product number
B5331
Product name
BIM189
Packaging
1mg
Price
$322
Updated
2021/12/16
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BIM189 Chemical Properties,Usage,Production

Biological Activity

bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors: one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 189 is a a new peptide of bombesin antagonis, while bim 187 is a bombesin agonist.

in vitro

bim 189 was one of the most potent bombesin antagonists known in the guinea pig and 3t3 cell systems but has 40% partial agonist activity in the rat. loss of agonism might be attributed to the cl electron withdrawing effects rather than the size of the cl since far larger na114 substitutions did not effect agonist activity [2].

in vivo

bim 187 at 4 μg/kg, significantly reduced food intake at 30 min in rat, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake when administered alone, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187[2].

IC 50

10.4 nm for rat pancreas; 2.4 nm for guinea pig pancreas

References

[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim 187) and a new antagonist (bim 189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8.

BIM189 Preparation Products And Raw materials

Raw materials

Preparation Products

142062-55-3, BIM189Related Search:


  • BIM189
  • L-Phenylalaninamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-4-chloro-
  • 142062-55-3
  • C56H73ClN14O10