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Zamifenacinfumarate

Product Name
Zamifenacinfumarate
CAS No.
127308-98-9
Chemical Name
Zamifenacinfumarate
Synonyms
UK-76654 fumarate;Zamifenacinfumarate;Zamifenacin fumarate, 10 mM in DMSO;Zamifenacin fumarate, M3 receptor antagonist;(3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidinefumarate;(R)-3-(Benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine fumarate;gut,UK 76654,bowel,inhibit,Inhibitor,Muscarinic acetylcholine receptor,UK-76654,muscarinic,mAChR,motility,syndrome,irritable,Zamifenacin fumarate,Zamifenacin,UK76654,colonic
CBNumber
CB81075168
Molecular Formula
C31H33NO7
Formula Weight
531.61
MOL File
127308-98-9.mol
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Zamifenacinfumarate Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble to 100 mM in DMSO and to 25 mM in ethanol
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
Z150705
Product name
ZamifenacinFumarate
Packaging
25mg
Price
$295
Updated
2021/12/16
ApexBio Technology
Product number
B7114
Product name
Zamifenacinfumarate
Packaging
10mg
Price
$315
Updated
2021/12/16
ChemScene
Product number
CS-0029052
Product name
Zamifenacin(fumarate)
Purity
99.77%
Packaging
10mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0029052
Product name
Zamifenacin(fumarate)
Purity
99.77%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0029052
Product name
Zamifenacin(fumarate)
Purity
99.77%
Packaging
25mg
Price
$780
Updated
2021/12/16
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Zamifenacinfumarate Chemical Properties,Usage,Production

Uses

Zamifenacin Fumarate is a selective antagonist of mAChR M3 (M3 muscarinic receptor).

Biological Activity

Selective M 3 muscarinic receptor antagonist (pK i values are 8.52, 7.93, 7.90 and 7.78 for M 3 , M 2 , M 1 and M 4 receptors respectively). Displays higher affinity at ileal M 3 receptors (pK i = 9.3) compared to oesophageal and tracheal M 3 receptors (pK i values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal motility in the absence of cardiovascular effects.

in vivo

Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and Cmax (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg)[2].
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].

Animal Model:Male CDl mice (mean weight 23 g)[2]
Dosage:5.3 mg/kg for i.v.; 13.2 mg/kg for oral (Pharmacokinetic Analysis)
Administration:Intravenous administration and oral administration
Result:Oral bioavailability (26%), Cmax (92 ng/mL), T1/2 (1.1 h).
Animal Model:Male and female CD rats (mean weight 210 g)[2]
Dosage:5.0 mg/kg for i.v.; 20 mg/kg for oral (Pharmacokinetic Analysis)
Administration:Intravenous administration and oral administration
Result:Oral bioavailability (64%), Cmax (905 ng/mL), T1/2 (6.0 h).
Animal Model:Male and two female beagle dogs (13-16 kg)[2]
Dosage:1.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis)
Administration:Intravenous administration and oral administration
Result:Oral bioavailability (100%), Cmax (416 ng/mL), T1/2 (1.1 h).

Zamifenacinfumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Zamifenacinfumarate Suppliers

China 28 Germany 1 The Netherlands 1 United Kingdom 1 United States 10 Global 41
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4941
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9992
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58

127308-98-9, ZamifenacinfumarateRelated Search:


  • Zamifenacinfumarate
  • (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidinefumarate
  • UK-76654 fumarate
  • (R)-3-(Benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine fumarate
  • gut,UK 76654,bowel,inhibit,Inhibitor,Muscarinic acetylcholine receptor,UK-76654,muscarinic,mAChR,motility,syndrome,irritable,Zamifenacin fumarate,Zamifenacin,UK76654,colonic
  • Zamifenacin fumarate, M3 receptor antagonist
  • Zamifenacin fumarate, 10 mM in DMSO
  • 127308-98-9
  • C27H29NO3C4H4O4