ChemicalBook > CAS DataBase List > Dizocilpine
Dizocilpine
- Product Name
- Dizocilpine
- CAS No.
- 77086-21-6
- Chemical Name
- Dizocilpine
- Synonyms
- C13737;Dizocilpine;MK-801 (Dizocilpine);Dizocilpine (MK-801);Dizocilpine USP/EP/BP;Dizocilpine free base;Dizocilpine, 10 mM in DMSO;Dizocilpine free base(MK801);(5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine;(5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
- CBNumber
- CB81075436
- Molecular Formula
- C16H15N
- Formula Weight
- 221.3
- MOL File
- 77086-21-6.mol
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Dizocilpine Property
- Melting point:
- 68.5-69°
- alpha
- 20589 +161.4° (c = 0.038 g/2 ml ethanol)
- Boiling point:
- 320.3±11.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 7.96±0.40(Predicted)
- color
- White to off-white
- EPA Substance Registry System
- 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- (77086-21-6)
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Safety
- Hazardous Substances Data
- 77086-21-6(Hazardous Substances Data)
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Dizocilpine Chemical Properties,Usage,Production
Uses
Neuroprotective.
Definition
ChEBI: Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).
in vivo
Dizocilpine maleate can be used to create schizophrenia models. An intraperitoneal injection of 0.2 mg/kg in SD rats results in a half-life of 52.31 minutes, an AUC of 3185.48 nM·min, and a clearance rate of 34 mL/min/kg[2].
Induction of Schizophrenia
Background
The specific mechanism of schizophrenia induction is unclear. One hypothesis is that, Dizocilpine maleateleads to dysregulation of glutamatergic system through NMDA inhibition[2].
Specific Modeling Methods
Rat: Sprague-Dawley ? male ? adult with weight of 250-300 g
Administration: 0.4 mg/kg ? i.p. ? single dose.
Administration: 0.4 mg/kg ? i.p. ? single dose.
Note
Dizocilpine maleate is dissolved in 0.9% sterile saline.
Modeling Indicators
Behavior: Increased spontaneous activity with obvious anxiety-like behavior, increased motor activity in longer diatance (hyperactivity), reduced time staying in central area (avoidance of central area).
Prepulse Inhibition (PPI): Decreased PPI significantly.
maze test:Avoided open arm entries in elevated plus maze test and reduced number of novel arm entries in Y maze test.
Prepulse Inhibition (PPI): Decreased PPI significantly.
maze test:Avoided open arm entries in elevated plus maze test and reduced number of novel arm entries in Y maze test.
Correlated Product(s): Phencyclidine
Opposite Product(s): Clozapine (HY-14539); Haloperidol (HY-14538)
IC 50
NMDA Receptor
Dizocilpine Preparation Products And Raw materials
Raw materials
Preparation Products
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Dizocilpine Suppliers
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3506
- Advantage
- 58
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- 15221275939
- Fax
- 021-50706099
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- Country
- China
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- Advantage
- 55
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- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9858
- Advantage
- 58
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- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4768
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- 55
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
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- China
- ProdList
- 6468
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- 55
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- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
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- China
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- 6687
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- 55
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- 021-61312847; 18021002903
- Fax
- QQ:3008007432
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- China
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- 857-239-0968
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- 857-239-8801
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- Country
- United States
- ProdList
- 2559
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- 400-1166-196 15982826727
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
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View Lastest Price from Dizocilpine manufacturers
Career Henan Chemical Co
- Product
- Dizocilpine 77086-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%HPLC
- Supply Ability
- 100KG
- Release date
- 2020-02-05