(6-aminopyridin-2-yl)methanol

(6-aminopyridin-2-yl)methanol Property

Melting point:

70℃

Boiling point:

299℃

Density 

1.257

Flash point:

134℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Slightly soluble.

pka

13.40±0.10(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C6H8N2O/c7-6-3-1-2-5(4-9)8-6/h1-3,9H,4H2,(H2,7,8)

InChIKey

YGMPMXTWKROXPP-UHFFFAOYSA-N

SMILES

C1(CO)=NC(N)=CC=C1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

(6-aminopyridin-2-yl)methanol Chemical Properties,Usage,Production

Uses

4-Aminopyridine (4-AP), a well-known potassium channel blocker, has been shown to enhance conduction in injured and demyelinated axons. Aminopyridine has a narrow therapeutic range in clinical application. In the current study, we investigated whether AP-MeOH can enhance impulse conduction in an animal model of MS.

References

[1] Patent: WO2006/134467, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: WO2006/106423, 2006, A2. Location in patent: Page/Page column 33-34