2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
- Product Name
- 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
- CAS No.
- 22433-12-1
- Chemical Name
- 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
- Synonyms
- 5-Bromopyrimidine-2-methanol;(5-bromopyrimidin-2-yl)methal;2-Pyrimidinemethanol, 5-bromo-;(5-BroMopyriMidin-2-yl)Methanol;(5-Bromo-2-pyrimidinyl)methanol;(5-bromopyrimidine-2-yl)methanol;5-Bromo-2-(hydroxymethyl)pyrimidine;2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
- CBNumber
- CB81081451
- Molecular Formula
- C5H5BrN2O
- Formula Weight
- 189.01
- MOL File
- 22433-12-1.mol
2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Property
- Melting point:
- 93-94 °C
- Boiling point:
- 263.7±20.0 °C(Predicted)
- Density
- 1.785±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.23±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H5BrN2O/c6-4-1-7-5(3-9)8-2-4/h1-2,9H,3H2
- InChIKey
- ZRHVXSBXNUJBGF-UHFFFAOYSA-N
- SMILES
- C1(CO)=NC=C(Br)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B688025
- Product name
- (5-Bromopyrimidin-2-yl)methanol
- Packaging
- 2.5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- Z4443
- Product name
- (5-Bromopyrimidin-2-yl)methanol
- Packaging
- 100mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- Z4443
- Product name
- (5-Bromopyrimidin-2-yl)methanol
- Packaging
- 5g
- Price
- $571
- Updated
- 2021/12/16
- Product number
- 123836
- Product name
- 5-Bromopyrimidine-2-methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $867
- Updated
- 2021/12/16
- Product number
- L22275
- Product name
- (5-Bromopyrimidin-2-yl)methanol
- Purity
- 97%
- Packaging
- 250MG
- Price
- $150
- Updated
- 2021/12/16
2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Chemical Properties,Usage,Production
Uses
(5-Bromopyrimidin-2-yl)methanol is used to prepare alcohol-?containing benzothiazoles as potent dual-?targeting bacterial DNA supercoiling inhibitors.
Synthesis
1025351-12-5
22433-12-1
General procedure for the synthesis of (5-bromopyrimidin-2-yl)methanol from the compound (CAS:1025351-12-5): (Step 4) Methyl (5-bromopyrimidin-2-yl)benzoate (7.30 g, 25.0 mmol) was dissolved in methanol (15 ml), to which a 1N sodium methanol/methanol solution (50.0 ml, 0.500 mmol) was added. The resulting mixture was stirred at room temperature until the deprotection reaction was complete. After completion of the reaction, the solvent was removed by distillation. The obtained residue was purified by silica gel column chromatography (eluent ratio: dichloromethane:methanol = 30:1 to 15:1) to afford the title compound (5-bromopyrimidin-2-yl)methanol (3.58 g, 76% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 8.80 (s, 2H), 4.82 (d, J=4.0 Hz, 2H), 3.39 (s, 1H).
References
[1] Patent: US2015/51395, 2015, A1. Location in patent: Paragraph 1531-1532
[2] Patent: US2016/244451, 2016, A1. Location in patent: Paragraph 0283; 0284; 0285
[3] Synlett, 2008, # 4, p. 543 - 546
2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Suppliers
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View Lastest Price from 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) manufacturers
- Product
- 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) 22433-12-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26