2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)

Product Name: 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
CAS No.: 22433-12-1
Chemical Name: 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
Synonyms: 5-Bromopyrimidine-2-methanol;(5-bromopyrimidin-2-yl)methal;2-Pyrimidinemethanol, 5-bromo-;(5-BroMopyriMidin-2-yl)Methanol;(5-Bromo-2-pyrimidinyl)methanol;(5-bromopyrimidine-2-yl)methanol;5-Bromo-2-(hydroxymethyl)pyrimidine;2-Pyrimidinemethanol, 5-bromo- (8CI,9CI)
CBNumber: CB81081451
Molecular Formula: C5H5BrN2O
Formula Weight: 189.01
MOL File: 22433-12-1.mol

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2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Property

Melting point:: 93-94 °C
Boiling point:: 263.7±20.0 °C(Predicted)
Density: 1.785±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.23±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C5H5BrN2O/c6-4-1-7-5(3-9)8-2-4/h1-2,9H,3H2
InChIKey: ZRHVXSBXNUJBGF-UHFFFAOYSA-N
SMILES: C1(CO)=NC=C(Br)C=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B688025
Product name: (5-Bromopyrimidin-2-yl)methanol
Packaging: 2.5g
Price: $1260
Updated: 2021/12/16

AK Scientific

Product number: Z4443
Product name: (5-Bromopyrimidin-2-yl)methanol
Packaging: 100mg
Price: $109
Updated: 2021/12/16

AK Scientific

Product number: Z4443
Product name: (5-Bromopyrimidin-2-yl)methanol
Packaging: 5g
Price: $571
Updated: 2021/12/16

Matrix Scientific

Product number: 123836
Product name: 5-Bromopyrimidine-2-methanol
Purity: 95+%
Packaging: 1g
Price: $867
Updated: 2021/12/16

ACHEMBLOCK

Product number: L22275
Product name: (5-Bromopyrimidin-2-yl)methanol
Purity: 97%
Packaging: 250MG
Price: $150
Updated: 2021/12/16

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2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Chemical Properties,Usage,Production

Uses

(5-Bromopyrimidin-2-yl)methanol is used to prepare alcohol-?containing benzothiazoles as potent dual-?targeting bacterial DNA supercoiling inhibitors.

Synthesis

1025351-12-5

22433-12-1

General procedure for the synthesis of (5-bromopyrimidin-2-yl)methanol from the compound (CAS:1025351-12-5): (Step 4) Methyl (5-bromopyrimidin-2-yl)benzoate (7.30 g, 25.0 mmol) was dissolved in methanol (15 ml), to which a 1N sodium methanol/methanol solution (50.0 ml, 0.500 mmol) was added. The resulting mixture was stirred at room temperature until the deprotection reaction was complete. After completion of the reaction, the solvent was removed by distillation. The obtained residue was purified by silica gel column chromatography (eluent ratio: dichloromethane:methanol = 30:1 to 15:1) to afford the title compound (5-bromopyrimidin-2-yl)methanol (3.58 g, 76% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 8.80 (s, 2H), 4.82 (d, J=4.0 Hz, 2H), 3.39 (s, 1H).

References

[1] Patent: US2015/51395, 2015, A1. Location in patent: Paragraph 1531-1532
[2] Patent: US2016/244451, 2016, A1. Location in patent: Paragraph 0283; 0284; 0285
[3] Synlett, 2008, # 4, p. 543 - 546

2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) Suppliers

China 70 Europe 1 India 1 United States 6 Global 78

Accela ChemBio Inc.

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Matrix Scientific

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View Lastest Price from 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Pyrimidinemethanol, 5-bromo- (8CI,9CI) 22433-12-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

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