(S)-CFT7455
- Product Name
- (S)-CFT7455
- CAS No.
- 2504235-67-8
- Chemical Name
- (S)-CFT7455
- Synonyms
- CFT7455;(S)-CFT7455;Cemsidomide;Cemsidomide (CFT7455);CFT7455, 10 mM in DMSO;(S)-3-(6-(4-(morpholinomethyl)benzyl)-2-oxobenzo[cd]indol-1(2H)-yl)piperidine-2,6-dione;(3S)-3-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxo-1-benzo[cd]indolyl]piperidine-2,6-dione;(S)-3-(6-(4-(Morpholinomethyl)benzyl)-2-oxobenzo[cd]indol-1(2H)-yl)piperidine-2,6-dione , Cemsidomide;2,6-Piperidinedione, 3-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-, (3S)-;cereblon,CFT 7455,Ligands for E3 Ligase,anti-cancer agent,inhibit,CFT-7455,Inhibitor,CFT7455,orally active,E3 ligase-recruiting Moiety,IKZF3 degrader,IKZF1
- CBNumber
- CB810828960
- Molecular Formula
- C28H27N3O4
- Formula Weight
- 469.54
- MOL File
- 2504235-67-8.mol
(S)-CFT7455 Property
- Boiling point:
- 738.0±60.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- solubility
- Acetonitrile: Sparingly Soluble: 1-10 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml - form
- Solid
- pka
- 10.70±0.40(Predicted)
- color
- Light yellow to green yellow
- InChIKey
- MUKCJOOKCZSQNW-FKEMPHOKNA-N
- SMILES
- C(C1C=CC(CN2CCOCC2)=CC=1)C1=CC=C2N([C@H]3CCC(=O)NC3=O)C(=O)C3C=CC=C1C2=3 |&1:19,r|
(S)-CFT7455 Chemical Properties,Usage,Production
Uses
Cemsidomide (CFT7455) is a ubiquitin ligase pathway Ikaros/Aiolos degrader with molecular glue activity[1]. Cemsidomide has a GI50 of 0.05 nM for NCIH929.1 cells.
in vivo
In mouse xenograft tumor models, Cemsidomide demonstrates dose dependent efficacy from 3 μg/kg/day to 100 μg/kg/day. In several tumor xenografts tested daily dosing of Cemsidomide at dose of 30 μg/kg/day to 100 μg/kg/day led to durable tumor regression[1].
Cemsidomide (0.1 mg/kg/day; for 21 days) promotes tumor regression in the H929 tumor xenograft model (95% tumor growth inhibition by 7 days)[2].
IC 50
Cereblon: 0.9 nM (Kd)
References
[1] David Proia, et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1.
[2] James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
(S)-CFT7455 Preparation Products And Raw materials
Raw materials
Preparation Products
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