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R-N-BENZYL-PROLINE

Product Name
R-N-BENZYL-PROLINE
CAS No.
56080-99-0
Chemical Name
R-N-BENZYL-PROLINE
Synonyms
benzyl-D-proline;N-Benzyl-D-proline;R-N-BENZYL-PROLINE;1-Benzyl-D-proline;D-Proline, 1-(phenylmethyl)-;(2R)-1-benzylpyrrolidine-2-carboxylic acid
CBNumber
CB81090912
Molecular Formula
C12H15NO2
Formula Weight
205.25
MOL File
56080-99-0.mol
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R-N-BENZYL-PROLINE Property

Boiling point:
343.1±35.0 °C(Predicted)
Density 
1.205±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2.35±0.20(Predicted)
form 
solid
color 
White to light yellow
optical activity
31.9°(C=1.00g/100ml MEOH)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B285105
Product name
(R)-1-Benzyl-pyrrolidine-2-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-RC
Product name
1-Benzyl-D-proline
Purity
97%
Packaging
1g
Price
$77
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-RC
Product name
1-Benzyl-D-proline
Purity
97%
Packaging
5G
Price
$292
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0041231
Product name
(R )-1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
5MG
Price
$497.27
Updated
2021/12/16
AK Scientific
Product number
1186AL
Product name
(R)-1-Benzyl-pyrrolidine-2-carboxylicacid
Packaging
25g
Price
$637
Updated
2021/12/16
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R-N-BENZYL-PROLINE Chemical Properties,Usage,Production

Uses

(R)-1-Benzylpyrrolidine-2-carboxylic acid is a proline derivative[1].

Synthesis

100-44-7

344-25-2

56080-99-0

General procedure for the synthesis of N-benzyl-D-proline from benzyl chloride and D-proline: a suspension of D-proline (115 g, 1 mol), potassium hydroxide (168.3 g, 3 mol) and isopropanol (1 L) was stirred at 40°C until the suspension became clear. Subsequently, benzyl chloride (137.3 g, 1.1 mol) was slowly added and stirring was continued at 40°C for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to 0-5°C and the pH was adjusted to 5-6 with concentrated hydrochloric acid (145 mL). the reaction mixture was diluted with chloroform (3 L) and stirred for 18 h. The reaction was purified by filtration. The resulting KCl was removed by filtration, the filtrate was concentrated and the crude product was recrystallized from acetone to give N-benzyl-D-proline in 79% yield (161.8 g). [39] The product was characterized as follows: 1H-NMR (CDCl3, ppm): δ 7.2-7.4 (m, 5H), 4.0-4.4 (dd, 2H), 3.8 (dd, 1H), 3.6-3.7 (m, 1H), 2.8 (dd, 1H), 1.8-2.4 (m, 4H). [40] Specific optical rotation [α]D25 = +28.4 (c = 1, EtOH). [41] Melting point 174-175°C.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

R-N-BENZYL-PROLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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R-N-BENZYL-PROLINE Suppliers

China 41 India 2 United Kingdom 1 United States 5 Global 49
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
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850
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64
Sphinx Scientific Laboratory (Tianjin) Co., Ltd.
Tel
022-66211289-843 13672102692
Fax
QQ：2377893365
Email
contact@sphinxpharm.com
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China
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361
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T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
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9895
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SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Fax
2469917557
Email
sunkai@chembiobanksh.com
Country
China
ProdList
2040
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Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
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42446
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Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
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904
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Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
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55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
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58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58

56080-99-0, R-N-BENZYL-PROLINERelated Search:

(R)-1-BENZYL-5-CARBOXY-2-PYRROLIDINONE (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE AKOS 91404 N-(3,5-Dinitrobenzoyl)-D-proline R-N-BENZYL-PROLINE N-BENZYL-D-PROLINE ETHYL ESTER 1-BENZYL-(2R,4R)-4-AMINO-PYRROLIDINE-2,4-DICARBOXYLIC ACID HCL

  • R-N-BENZYL-PROLINE
  • N-Benzyl-D-proline
  • (2R)-1-benzylpyrrolidine-2-carboxylic acid
  • 1-Benzyl-D-proline
  • D-Proline, 1-(phenylmethyl)-
  • benzyl-D-proline
  • 56080-99-0