2-AMINO-3-FLUOROBENZONITRILE

Product Name: 2-AMINO-3-FLUOROBENZONITRILE
CAS No.: 115661-37-5
Chemical Name: 2-AMINO-3-FLUOROBENZONITRILE
Synonyms: 2-Cyano-6-fluoroaniline;Amino-3-fluorobenzonitrile;2-Amino-3-fluorobenzonitrile;Benzonitrile, 2-amino-3-fluoro-;2-Amino-3-fluorobenzonitrile,95%;2-Cyano-6-fluoroaniline, 3-Fluoroanthranilonitrile
CBNumber: CB81091595
Molecular Formula: C7H5FN2
Formula Weight: 136.13
MOL File: 115661-37-5.mol

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2-AMINO-3-FLUOROBENZONITRILE Property

Boiling point:: 252.4±25.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.42±0.10(Predicted)
form: Solid
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C7H5FN2/c8-6-3-1-2-5(4-9)7(6)10/h1-3H,10H2
InChIKey: UNISSOLHERSZOW-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=CC(F)=C1N

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Safety

HazardClass: TOXIC
HazardClass: 6.1
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A898103
Product name: 2-Amino-3-fluorobenzonitrile
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC9826
Product name: 2-Amino-3-fluorobenzonitrile
Purity: 97%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 066864
Product name: 2-Amino-3-fluorobenzonitrile
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3637-3-65
Product name: 2-Amino-3-fluorobenzonitrile
Packaging: 1g
Price: $16
Updated: 2021/12/16

Apolloscientific

Product number: PC9826
Product name: 2-Amino-3-fluorobenzonitrile
Purity: 97%
Packaging: 5g
Price: $32
Updated: 2021/12/16

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2-AMINO-3-FLUOROBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

brown liquid

Uses

2-Amino-3-fluorobenzonitrile is used as an intermediate in organic synthesis and medicinal chemistry, and is mostly used in basic chemical research and modification of pharmaceutical molecules.

Synthesis

21524-39-0

115661-37-5

The general procedure for the synthesis of 2-amino-3-fluorobenzonitrile from 2,3-difluorobenzonitrile was as follows: a mixture of 2,3-difluorobenzonitrile (19.0 g, 137 mmol), pre-saturated with ammonia, and ethanol (200 mL) was placed in an autoclave and heated for 8 hr at 140 °C (final pressure 200 psi). Upon completion of the reaction, the mixture was cooled to room temperature and evaporated to dryness. The residue was dissolved in water (400 mL) and extracted with ether (2 x 300 mL). The organic phases were combined, washed sequentially with water (300 mL) and brine (250 mL), and then dried over anhydrous magnesium sulfate. After drying, the solvent was filtered and evaporated. The resulting solid was ground with isohexane (150 mL) to give 2-amino-3-fluorobenzonitrile (9.8 g, 50% yield) as an off-white solid. Its 1H NMR (360 MHz, CDCl3) data were as follows: δ 4.47 (2H, s), 6.65-6.71 (1H, m), 7.14-7.20 (2H, m).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 2, p. 278 - 292
[2] Patent: US2003/55060, 2003, A1
[3] Patent: WO2003/99816, 2003, A1. Location in patent: Page 55
[4] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 36
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 4, p. 1235 - 1238

2-AMINO-3-FLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-3-FLUOROBENZONITRILE Suppliers

China 135 India 1 United Kingdom 3 United States 11 Global 150

HBCChem, Inc.

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Accela ChemBio Inc.

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Matrix Scientific

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HBCChem, Inc.

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HBCChem Inc.

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View Lastest Price from 2-AMINO-3-FLUOROBENZONITRILE manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 2-amino-3-fluorobenzonitrile 115661-37-5
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-04-21

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 2-AMINO-3-FLUOROBENZONITRILE 115661-37-5
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-AMINO-3-FLUOROBENZONITRILE 115661-37-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

115661-37-5, 2-AMINO-3-FLUOROBENZONITRILERelated Search:

4-AMINO-2,3,5,6-TETRAFLUOROBENZONITRILE 3-Fluoro-4-piperazinylbenzenecarbonitrile 2-CHLORO-4-CYANO-3,5,6-TRIFLUOROPHENYLHYDRAZINE BUTTPARK 144\07-23 2-Amino-5-fluoro-4-nitrobenzonitrile 3-Fluoro-4-nitrobenzonitrile 2,3,5,6-TETRAFLUORO-4-HYDRAZINOBENZONITRILE 4-Amino-2-chloro-3-fluorobenzonitrile BUTTPARK 35\03-63 2-AMINO-3-FLUOROBENZONITRILE 4-AMINO-2,5-DIFLUOROBENZONITRILE 2-AMINO-3,5,6-TRIFLUOROTEREPHTHALONITRILE 2,5-Difluoro-4-(hydrazino)-benzonitrile 3-Fluoro-2-nitrobenzonitrile

2-Amino-3-fluorobenzonitrile

2-Cyano-6-fluoroaniline

2-Cyano-6-fluoroaniline, 3-Fluoroanthranilonitrile

Benzonitrile, 2-amino-3-fluoro-

Amino-3-fluorobenzonitrile

2-Amino-3-fluorobenzonitrile,95%

115661-37-5

Fluorine series