ethyl 5-amino-1H-pyrazole-3-carboxylate
- Product Name
- ethyl 5-amino-1H-pyrazole-3-carboxylate
- CAS No.
- 105434-90-0
- Chemical Name
- ethyl 5-amino-1H-pyrazole-3-carboxylate
- Synonyms
- EOS-61138;MFCD09991917;Ethyl 5-aminopyrazole-3-carboxylate;Ethyl 5-amino-1H-pyrazol-3-carboxylate;ethyl 5-amino-2H-pyrazole-3-carboxylate;ethyl 5-amino-1H-pyrazole-3-carboxylate;5-Amino-3-pyrazolecarboxylic acid ethyl ester;5-Amino pyrazole-3-carboxylic acid ethyl ester;Ethyl 5-Amino-1H-Pyrazole-3-Carboxylate(WX609158);5-amino-2H-pyrazole-3-carboxylic acid ethyl ester
- CBNumber
- CB81094187
- Molecular Formula
- C6H9N3O2
- Formula Weight
- 155.15
- MOL File
- 105434-90-0.mol
ethyl 5-amino-1H-pyrazole-3-carboxylate Property
- Boiling point:
- 391.9±22.0 °C(Predicted)
- Density
- 1.318
- storage temp.
- 2-8°C(protect from light)
- pka
- 12.32±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
- InChI
- InChI=1S/C6H9N3O2/c1-2-11-6(10)4-3-5(7)9-8-4/h3H,2H2,1H3,(H3,7,8,9)
- InChIKey
- CPQKGGOPHDHAMN-UHFFFAOYSA-N
- SMILES
- N1C(N)=CC(C(OCC)=O)=N1
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A628910
- Product name
- 5-Amino-1H-pyrazole-3-carboxylicAcidEthylEster
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- A628910
- Product name
- 5-Amino-1H-pyrazole-3-carboxylicAcidEthylEster
- Packaging
- 10g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- CHM0090594
- Product name
- ETHYL 3-AMINO-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $866.25
- Updated
- 2021/12/16
- Product number
- CHM0090594
- Product name
- ETHYL 3-AMINO-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $770
- Updated
- 2021/12/16
- Product number
- CS-W018572
- Product name
- Ethyl5-amino-1H-pyrazole-3-carboxylate
- Purity
- 98.54%
- Packaging
- 10g
- Price
- $145
- Updated
- 2021/12/16
ethyl 5-amino-1H-pyrazole-3-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 5-amino-1H-pyrazole-3-carboxylate was used for the synthetic preparation of 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids, an highly potent agonists of GPR109b.
Synthesis
39846-84-9
105434-90-0
General procedure for the synthesis of ethyl 5-amino-pyrazole-3-carboxylate from ethyl 5-nitro-1H-pyrazole-3-carboxylate: ethyl 5-nitro-1H-pyrazole-3-carboxylate (0.925 g, 0.500 mmol) was dissolved in anhydrous ethanol (10 mL) and 10% Pd/C catalyst (0.100 g) was added. The reaction mixture was stirred at room temperature for 18 h under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford the green solid product ethyl 5-amino-pyrazole-3-carboxylate (0.70 g, 90% yield). The product was confirmed by NMR hydrogen spectrum (1H NMR, CD3OD): δ 6.0 (s, 1H), 4.3 (q, 2H, J = 7.1 Hz, CO2CH2CH3), 1.4 (t, 3H, J = 7.1 Hz, CO2CH2CH3). Mass spectrum (ESI+): m/z 156 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4207 - 4209
[2] Patent: WO2006/127595, 2006, A1. Location in patent: Page/Page column 62
[3] Patent: WO2006/126695, 2006, A1. Location in patent: Page/Page column 246-247
[4] Patent: US2007/32529, 2007, A1
[5] Patent: US2009/36450, 2009, A1. Location in patent: Page/Page column 21
ethyl 5-amino-1H-pyrazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 5-amino-1H-pyrazole-3-carboxylate manufacturers
- Product
- ethyl 5-amino-1H-pyrazole-3-carboxylate 105434-90-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-21