Fradafiban
- Product Name
- Fradafiban
- CAS No.
- 148396-36-5
- Chemical Name
- Fradafiban
- Synonyms
- BIBU-52;Fradafiban;Fradafiban/BIBU-52;3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)-
- CBNumber
- CB81117082
- Molecular Formula
- C20H21N3O4
- Formula Weight
- 367.403
- MOL File
- 148396-36-5.mol
Fradafiban Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.29±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0011523
- Product name
- FRADAFIBAN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.13
- Updated
- 2021/12/16
Fradafiban Chemical Properties,Usage,Production
Uses
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
Definition
ChEBI: A pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl gr up (the S,S-diastereoisomer). A figrinogen receptor antagonist.
in vivo
Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].
References
[1] Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8. DOI:10.1161/01.cir.96.4.1130
Fradafiban Preparation Products And Raw materials
Raw materials
Preparation Products
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