Nebidrazine

Product Name: Nebidrazine
CAS No.: 55248-23-2
Chemical Name: Nebidrazine
Synonyms: FLA 136;Nebidrazine;2,6-Dichlorobenzaldehyde (4-amino-4H-1,2,4-triazol-3-yl)hydrazone;Benzaldehyde, 2,6-dichloro-, 2-(4-amino-4H-1,2,4-triazol-3-yl)hydrazone;3-N-[(E)-(2,6-dichlorophenyl)methylideneamino]-1,2,4-triazole-3,4-diamine
CBNumber: CB81118423
Molecular Formula: C9H8Cl2N6
Formula Weight: 271.11
MOL File: 55248-23-2.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0016634
Product name: NEBIDRAZINE
Purity: 95.00%
Packaging: 5MG
Price: $496.32
Updated: 2021/12/16

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Nebidrazine Chemical Properties,Usage,Production

Uses

Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation[1].

References

[1] A COMPARISON OF THE CARDIOVASCULAR AND SEDATIVE ACTIONS OF THE x-ADRENOCEPTOR AGONISTS, FLA-136 AND CLONIDINE, IN THE RAT

Nebidrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Nebidrazine Suppliers

China 2 United Kingdom 1 United States 3 Global 6

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29496
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

55248-23-2, NebidrazineRelated Search:

2,6-Dichlorobenzaldehyde 2,6-DICHLOROBENZALDEHYDE 1-(4-AMINO-5-ETHYL-4H-1,2,4-TRIAZOL-3-YL)HYDRAZONE Nebidrazine

Nebidrazine

FLA 136

2,6-Dichlorobenzaldehyde (4-amino-4H-1,2,4-triazol-3-yl)hydrazone

Benzaldehyde, 2,6-dichloro-, 2-(4-amino-4H-1,2,4-triazol-3-yl)hydrazone

3-N-[(E)-(2,6-dichlorophenyl)methylideneamino]-1,2,4-triazole-3,4-diamine

55248-23-2

C9H8Cl2N6