2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
- Product Name
- 2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
- CAS No.
- 166591-85-1
- Chemical Name
- 2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
- Synonyms
- MG 310;2-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid;N-Boc-1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid;REF DUPL: 2-N-Boc-1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid;2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid;3,4-Dihydro-1,2(1H)-isoquinolinedicarboxylic acid 2-(1,1-dimethylethyl) ester;1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-dimethylethyl) ester
- CBNumber
- CB81119248
- Molecular Formula
- C15H19NO4
- Formula Weight
- 277.32
- MOL File
- 166591-85-1.mol
2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Property
- Boiling point:
- 436.7±45.0 °C(Predicted)
- Density
- 1.222±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.49±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000460540
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- P000460540
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
- Product number
- P000460540
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $555
- Updated
- 2021/12/16
- Product number
- W3623
- Product name
- N-Boc-1,2,3,4-Tetrahydro-isoquinoline-1-carboxylicacid
- Packaging
- 5g
- Price
- $671
- Updated
- 2021/12/16
- Product number
- P000460540
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $836
- Updated
- 2021/12/16
2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
41034-52-0
24424-99-5
166591-85-1
To a stirred mixture of (±)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (150 mg, 0.85 mmol) and dichloromethane (1.69 mL) was added di-tert-butyl dicarbonate (185 mg, 0.85 mmol) and triethylamine (177 μL, 1.27 mmol) sequentially at 0 °C. The reaction mixture was gradually warmed to room temperature with continuous stirring overnight. Upon completion of the reaction, the pH was adjusted to 3.0 with 1.0 N aqueous hydrochloric acid, followed by extraction of the reaction mixture with ethyl acetate (3 × 25 mL). The organic phases were combined, washed with saturated aqueous sodium chloride (50 mL), dried over anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to afford 2-N-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (235 mg, 100% yield). Mass spectral data (m/z): 222 ([M + 2H - t-Bu]+), 300 ([M + Na]+), 577 ([2M + Na]+).
References
[1] Patent: WO2015/94902, 2015, A1. Location in patent: Page/Page column 22
[2] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 3, p. 314 - 319
[4] Patent: US5391705, 1995, A
2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID manufacturers
- Product
- 2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID 166591-85-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-30