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Ambruticin

Product Name
Ambruticin
CAS No.
58857-02-6
Chemical Name
Ambruticin
Synonyms
W7783;W-7783;W 7783;Ambruticin;(+)-ambruticin S;L-gluco-Non-8-enonic acid, 3,7-anhydro-2,4,8,9-tetradeoxy-9-[(1S,2S,3R)-2-[(1E,3R,4E)-5-[(2R,6R)-6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-yl]-3-methyl-1,4-hexadien-1-yl]-3-methylcyclopropyl]-, (8E)-
CBNumber
CB81120046
Molecular Formula
C28H42O6
Formula Weight
474.634
MOL File
58857-02-6.mol
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Safety

Toxicity
LD50 intravenous in mouse: 315mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PXT0005298
Product name
AMBRUTICIN
Purity
95.00%
Packaging
5MG
Price
$495.02
Updated
2021/12/16
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Ambruticin Chemical Properties,Usage,Production

Originator

Ambruticin,Universitet Karlsruhe (TH)

Uses

Antifungal.

Therapeutic Function

Antifungal

in vivo

The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge[2].

Animal Model:Guinea pigs (infected with a strain of T. mentagrophytes)[2]
Dosage:40 mg/kg
Administration:Oral, starting on day 3 postinfection, twice daily for a total of 10 days
Result:On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed.

Ambruticin Preparation Products And Raw materials

Raw materials

Preparation Products

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Ambruticin Suppliers

China 3 South Korea 1 United States 1 Global 5
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29423
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

58857-02-6, AmbruticinRelated Search:

DIMETHALLYL ETHER 3-ALLYLOXYPROPIONIC ACID Ambruticin (Tetrahydro-pyran-2-yl)acetic acid

  • Ambruticin
  • (+)-ambruticin S
  • L-gluco-Non-8-enonic acid, 3,7-anhydro-2,4,8,9-tetradeoxy-9-[(1S,2S,3R)-2-[(1E,3R,4E)-5-[(2R,6R)-6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-yl]-3-methyl-1,4-hexadien-1-yl]-3-methylcyclopropyl]-, (8E)-
  • W 7783
  • W7783
  • W-7783
  • 58857-02-6
  • C28H42O6