Mildiomycin Property

Melting point:

>300° (monohydrate)

alpha 

D20 +100° (c = 0.5 in water); +78.5° (c = 0.5 in 0.1N HCl)

Density 

1.81±0.1 g/cm3(Predicted)

pka

2.8, 4.3, 7.2, >12(at 25℃)

Safety

Toxicity

LD50 in rats, mice: ~500-1000 mg/kg i.v.; ~2.5-5.0 g/kg orally (Harada, Kishi)

Hazard and Precautionary Statements (GHS)

Mildiomycin Chemical Properties,Usage,Production

Description

Mildiomycin is a nucleoside antibiotic isolated from the culture filtrate of Streptoverticillium rimofaciens B-98891 (17). C19H30N8O9 (514.5). Basic and hygroscopic. Solubility: In water 580 g/L; in methanol 480; ethanol 160 (mg/L). Insoluble in ethyl acetate and ethyl ether. Susceptible to photodegradation by sunlight.

Uses

Specifically active against the powdery mildew pathogens; excellent curative activity on the disease of various plants in vivo.Used in practice for the control of powderymildews on rose, spindle tree, and Indian lilac.

Toxicity evaluation

Mildiomycin remarkably inhibits protein synthesis in E. coli. The synthesis of polypeptides in mammalian cellfree system from rabbit reticulocytes is less sensitive to mildiomycin than that from E. coli (18). The toxicity of mildiomycin is low; LD₅₀ for acute toxicity in rats and mice is 500–1000 mg/kg by intravenous and subcutaneous injections, and 2.5–5.0 g/kg by oral administration. At a concentration of 1000 ppm, there is no irritation to the cornea and skin of rabbits for 10 days.