ChemicalBook > CAS DataBase List > Bis(maltolato)oxovanadium(IV)

Bis(maltolato)oxovanadium(IV)

Product Name: Bis(maltolato)oxovanadium(IV)
CAS No.: 38213-69-3
Chemical Name: Bis(maltolato)oxovanadium(IV)
Synonyms: BMOV;BIS(MALTOLATO)OXOVANADIUM;BIS(MALTOLATO)OXOVANADIUM(IV);Bis(maltolato)oxovanadium(IV), 10 mM in DMSO;oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate);(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM;Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-;Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium;type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes
CBNumber: CB8113685
Molecular Formula: C12H10O7V
Formula Weight: 317.15
MOL File: 38213-69-3.mol

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Bis(maltolato)oxovanadium(IV) Property

Melting point:: >300°C (dec.)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: powder
color: yellow to grey to brown
LogP: 0.079 (est)

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Safety

RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1079
Product name: BMOV
Purity: ≥95% (elemental analysis)
Packaging: 10mg
Price: $78.9
Updated: 2025/07/31

TRC

Product number: B478500
Product name: Bis(maltolato)oxovanadium(IV)
Packaging: 5g
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18735
Product name: Bis(maltolato)oxovanadium(IV)
Packaging: 10g
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18735
Product name: Bis(maltolato)oxovanadium(IV)
Packaging: 25g
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0067486
Product name: Bis(maltolato)oxovanadium(IV)
Purity: ≥99.0%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

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Bis(maltolato)oxovanadium(IV) Chemical Properties,Usage,Production

Chemical Properties

Dark Purple Solid

Uses

It is a potent insulin mimic. Results showed that a promising outlook as an oral glucose-lowering drug.

Pharmaceutical Applications

Bis(maltolato)oxovanadium (BMOV) has proven itself as a successful antidiabetic agent when tested in animalmodels. Nevertheless, only very little is known about its mode of action. It is believed that BMOV acts as a competitive and reversible inhibitor of the enzyme protein tyrosine phosphatase (PTP).
As previously mentioned, BMOV is believed to be a potent and competitive inhibitor of the PTP1B activity and additionally seem to support the autophosphorylation of the insulin receptor leading to an increased sensitivity towards insulin. Research has shown that varying the organic ligand has an influence on the effectiveness and bioavailability of the resulting vanadium compound. It is believed that factors such as absorption, tissue uptake and distribution are affected most. Interestingly enough, X-ray crystal data of PTP1B soaked with BMOV showed only vanadate [V(+V)O₄^3?] at the active site. This would emphasise that the organic ligands are only carriers of the active compound and play no role in the enzyme inhibition itself. Furthermore, in aqueous solution, V(IV) is rapidly and reversibly oxidised to V(V), supporting the possible formation of vanadate.

Biological Activity

BMOV is a potent, orally available vanadium complex th at acts as insulin mimetic. Apparently, BMOV anti-diabetic effect results from enhancement of the tyrosine-phosphorylation of insulin receptor by inhibition of the protein tyrosine phosphatase-1B (PTP-1B). In diabetic rats BMOV restores normoglycaemia without rising insulin levels. BMOV is a potent phosphatase inhibitor.

in vivo

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice^[1].

Animal Model:	C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)^[1]
Dosage:	0.75-3.0 mmol
Administration:	Intraperitoneal injection; twice weekly; for 6 weeks
Result:	Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

Bis(maltolato)oxovanadium(IV) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bis(maltolato)oxovanadium(IV) manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Bis(maltolato) oxo vanadium 38213-69-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Bis(maltolato) oxo vanadium 38213-69-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-05

Henan Bao Enluo International TradeCo.，LTD

Product: Bis(maltolato) oxo vanadium 38213-69-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-08-01

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type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes

Bis(maltolato)oxovanadium(IV), 10 mM in DMSO

38213-69-3

C12H10O7V

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals