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MORACIZINE HYDROCHLORIDE

Product Name
MORACIZINE HYDROCHLORIDE
CAS No.
29560-58-5
Chemical Name
MORACIZINE HYDROCHLORIDE
Synonyms
en313;etmozin;ethmozine;ethmosine;MORACIZINE HCL;Moricizine hydrochloride;MORACIZINE HYDROCHLORIDE;Moricizine Hydrochloride (250 mg);Moricizine Hydrochloride (1446950);ethyl10-(3-morpholinopropionyl)phenothiazine-2-carbamatehydrochloride
CBNumber
CB8115063
Molecular Formula
C22H26ClN3O4S
Formula Weight
463.98
MOL File
29560-58-5.mol
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MORACIZINE HYDROCHLORIDE Property

Melting point:
189° (dec)
form 
Solid
color 
Off-white to light brown
EPA Substance Registry System
Moricizine hydrochloride (29560-58-5)
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Safety

HS Code 
2934302700
Toxicity
LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M635030
Product name
MoricizineHydrochloride
Packaging
100mg
Price
$1260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003427
Product name
MORACIZINE HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$255.15
Updated
2021/12/16
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MORACIZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Moricizine hydrochloride is a phenothiazine derivative with antiarrhythmic activity developed by the Soviet Academy of Medical Sciences. It is licensed to Dupont-Sanko in a joint venture. Moricizine hydrochloride is the first drug licensed to a U.S. company by the Soviet Union and was introduced by Dupont in the U.S. in 1990 for specific use in Iife-threatening ventricular arrhythmias. This narrow indication reflects its proarrhythmic potential. The incidence of this adverse reaction, however, is lower than that of other antiarrhythmic agents.

Originator

Acad. Med. Sci. (USSR)

Uses

Cardiac depressant (anti-arrhythmic).

Uses

Moricizine Hydrochloride is a Phenothiazine (P318040) derivative, which It was used as an antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.

Definition

ChEBI: A hydrochloride salt obtained from equimola amounts of moricizine and hydrogen chloride.

Manufacturing Process

To a solution of 10 g (0.035 mole) of ethyl phenthiazine-2-carbamate in 30 ml of anhydrous toluene is added dropwise 5.3 g (0.042 mole) of 3- chloropropionyl chloride, and the mixture is refluxed at 110-120°C for 4 hours, followed by clarifying the mixture with activated carbon and cooling it to room temperature. A precipitate of ethyl 10-(3-chloropropionyl)- phenthiazine-2-carbamate is removed by filtration. The yield is 10.2 g (77.5% of the theoretical amount), M.P. 169-170°C.
10.2 g of ethyl 10-(3-chloropropionyl)-phenthiazine-2-carbamate ester is dissolved in 50 ml of toluene, 4.72 g of morpholine is added thereto, and the mixture is refluxed at 110-120°C for a period of 3 hours. A precipitate of morpholine hydrochloride is removed by filtration, and the filtrate is washed with water in order to remove excess morpholine, followed by acidulating with dilute hydrochloric acid to adjust the pH of the filtrate is adjusted at 3. The acidic aqueous layer is separated, clarified by treatment with activated carbon and made alkaline until the pH equals 8-9. This procedure yields the free base of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-carbamate, M.P. 156- 157°C.
The free base thus obtained is extracted with toluene, the extract is dried over magnesium sulphate and to the anhydrous toluene solution is added an anhydrous ethereal solution of hydrogen chloride until the precipitation of the target compound is complete. This procedure yields 9.53 g (76.2% of the theoretical amount) of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2- carbamate hydrochloride. After recrystallization from dichloroethane, the target compound melts at 189°C. (decomp.).

brand name

Ethmozine (Shire).

Therapeutic Function

Antiarrhythmic

MORACIZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MORACIZINE HYDROCHLORIDE Suppliers

Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
Advantage
68
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12837
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34553
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Zhengzhou Akem Chemical Co., Ltd
Tel
13303867194
Email
3001317055@qq.com
Country
China
ProdList
9981
Advantage
58
Hunan Zhangjiajie Hengkang Biological Pharmaceutical Co., LTD
Tel
0731-85561023 18973109536
Email
hengkangapi@hengkangapi.com
Country
China
ProdList
394
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
Advantage
58
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View Lastest Price from MORACIZINE HYDROCHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
MORACIZINE HYDROCHLORIDE 29560-58-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-13

29560-58-5, MORACIZINE HYDROCHLORIDERelated Search:


  • [10-[3-(4-morpholinyl)-1-oxopropyl]-10h-phenothiazin-2-yl]-carbamicacieth
  • en313
  • ethmosine
  • ethmozine
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  • ethyletherof10-(beta-morpholylpropionyl)phenthiazinecarbaminoacidhydroch
  • etmozin
  • phenothiazine-2-carbamicacid,10-(3-morpholinopropionyl)-,ethylester,hydroc
  • MORACIZINE HCL
  • MORACIZINE HYDROCHLORIDE
  • Moricizine hydrochloride
  • 10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl carbaminoic acid, ethyl esterhydrochloride
  • Moricizine Hydrochloride (250 mg)
  • Moricizine Hydrochloride (1446950)
  • 29560-58-5
  • 29560-58-8
  • C22H25N3O4SHCl
  • C22H25N3O4SClH