2-METHOXY-6-NITRO-PHENYLAMINE
- Product Name
- 2-METHOXY-6-NITRO-PHENYLAMINE
- CAS No.
- 16554-45-3
- Chemical Name
- 2-METHOXY-6-NITRO-PHENYLAMINE
- Synonyms
- Einecs 240-617-4;6-nitro-o-anisidine;2-amino-3-nitroanisole;Methoxy-6-nitroaniline;2-METHOXY-6-NITROANILINE;2-Nitro-6-(methoxy)aniline;2-methoxy-6-nitrobenzenamine;2-METHOXY-6-NITRO-PHENYLAMINE;BenzenaMine, 2-Methoxy-6-nitro-;2-Methoxy-6-Nitrophenylamine95%
- CBNumber
- CB8116833
- Molecular Formula
- C7H8N2O3
- Formula Weight
- 168.15
- MOL File
- 16554-45-3.mol
2-METHOXY-6-NITRO-PHENYLAMINE Property
- Melting point:
- 73-78℃
- Boiling point:
- 322.1±22.0 °C(Predicted)
- Density
- 1.318±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- -0.35±0.25(Predicted)
- color
- Light yellow to brown
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS020857
- Product name
- 2-Methoxy-6-nitroaniline
- Packaging
- 100 mg
- Price
- $36.7
- Updated
- 2025/07/31
- Product number
- M220665
- Product name
- 2-Methoxy-6-nitroaniline
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J99640
- Product name
- 2-Methoxy-6-nitrophenylamine
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- CS-W007950
- Product name
- 2-Methoxy-6-nitrophenylamine
- Purity
- 99.83%
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 074068
- Product name
- 2-Methoxy-6-nitrophenylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
2-METHOXY-6-NITRO-PHENYLAMINE Chemical Properties,Usage,Production
Uses
2-Methoxy-6-nitroaniline is useful for preparing pyrimidine derivatives as FGFR4 inhibitors.
Synthesis
603-85-0
74-88-4
16554-45-3
Step 1: Synthesis of 2-methoxy-6-nitroaniline; A mixture of 2-amino-3-nitrophenol (11.66 g, 76 mmol) and potassium carbonate (K2CO3, 12.55 g, 91 mmol) was stirred in N,N-dimethylformamide (DMF, 100 mL) for 1 hour. Subsequently, a solution of iodomethane (5.68 mL, 91 mmol) in DMF (10 mL) was added dropwise and the reaction mixture was continued to be stirred for 14 hours. After completion of the reaction, the reaction mixture was diluted with distilled water (H2O) and extracted with ethyl acetate (EtOAc, 2 × 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give a dark solid. The crude product was purified by recrystallization from hexane to give 2-amino-3-nitroanisole as an orange solid (11.6 g, 91% yield). Liquid chromatography-mass spectrometry (LCMS, ES+) showed m/z 169.0 ([M + H]+).
References
[1] Patent: WO2012/40040, 2012, A1. Location in patent: Page/Page column 47-48
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5352 - 5362
[3] Patent: US2012/88767, 2012, A1. Location in patent: Page/Page column 16; 22
[4] Journal of Asian Natural Products Research, 2011, vol. 13, # 4, p. 330 - 340
[5] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 222 - 232
2-METHOXY-6-NITRO-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHOXY-6-NITRO-PHENYLAMINE Suppliers
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
View Lastest Price from 2-METHOXY-6-NITRO-PHENYLAMINE manufacturers
- Product
- 2-METHOXY-6-NITRO-PHENYLAMINE 16554-45-3
- Price
- US $80.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-27
- Product
- 2-Methoxy-6-nitroaniline 16554-45-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- 2-METHOXY-6-NITRO-PHENYLAMINE 16554-45-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23