Azumolene Sodium Salt

Product Name: Azumolene Sodium Salt
CAS No.: 105336-14-9
Chemical Name: Azumolene Sodium Salt
Synonyms: EU 4093;Azumolene Sodium Salt;Azumolene sodium anhydrous;AzumolenesodiumanhydrousAzumolenesodiumanhydrous;1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Sal;1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Salt
CBNumber: CB81176139
Molecular Formula: C13H10BrN4NaO3
Formula Weight: 373.14
MOL File: 105336-14-9.mol

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Azumolene Sodium Salt Property

Melting point:: >240°C (dec.)
storage temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility: Acetonitrile (Slightly), DMSO (Slightly), Water (Slightly)
form: Solid
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16462
Product name: Azumolene (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16462
Product name: Azumolene (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16462
Product name: Azumolene (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

TRC

Product number: A965300
Product name: AzumoleneSodiumSalt
Packaging: 10mg
Price: $180
Updated: 2021/12/16

TRC

Product number: A965300
Product name: AzumoleneSodiumSalt
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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Azumolene Sodium Salt Chemical Properties,Usage,Production

Description

Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 μM azumolene causing a 70% reduction in SOCE in myotubes. Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Skeletal muscle relaxant

Definition

ChEBI: Azumolene sodium is the anhydrous sodium salt of azumolene. It contains an azumolene(1-).

References

[1] S S PALNITKAR. Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.[J]. Biochemical Journal, 1997, 326 ( Pt 3): 847-852. DOI: 10.1042/bj3260847
[2] G.C. LESLIE N. J P. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat[J]. British Journal of Pharmacology, 1989, 97 4: 1151-1156. DOI: 10.1111/j.1476-5381.1989.tb12573.x
[3] XIAOLI ZHAO. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.[J]. The Journal of Biological Chemistry, 2006, 281 44: 33477-33486. DOI: 10.1074/jbc.m602306200
[4] VIKTOR YAROTSKYY R T D Feliciano Protasi. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.[J]. PLoS ONE, 2013: e77633. DOI: 10.1371/journal.pone.0077633

Azumolene Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Azumolene Sodium Salt Suppliers

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105336-14-9, Azumolene Sodium SaltRelated Search:

Azumolene 5-(4-BROMOPHENYL)-1,3-OXAZOLE Azumolene Sodium Salt DIFORMYLIMIDE SODIUM SALT

1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Sal

EU 4093

Azumolene Sodium Salt

1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Salt

AzumolenesodiumanhydrousAzumolenesodiumanhydrous

Azumolene sodium anhydrous

105336-14-9

C13H9BrN4NaO3

C13H8BrN4NaO3

Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals

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Intermediates & Fine Chemicals

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