Diethylaminoethyl Property

Melting point:

161-162 °C

Boiling point:

180-185 °C(Press: 2 Torr)

Density 

1.0500 g/cm3

pka

9.20±0.25(Predicted)

Hazard and Precautionary Statements (GHS)

Diethylaminoethyl Chemical Properties,Usage,Production

Originator

Aprofene,ZYF Pharm Chemical

Manufacturing Process

32 parts of α,α-diphenylpropionic acid chloride (made from diphenylpropionic acid and thionyl chloride, B.P./12 mm 170°C) are mixed with 50 parts of diethylaminoethanol. The mixture is heated for two hours to 150°-160°C. It is then suspended in dilute hydrochloric acid. The solution is treated with ether. After separation of the aqueous solution, the base is precipitated with sodium hydroxide solution and suspended in ether.
After removal of the ether by distillation, the residue is distilled in a vacuum. α,α-Diphenylpropionic acid β-diethylaminoethyl ester is obtained as a thick oil by distilling under 2 mm pressure at 180°-185°C. It is readily soluble in diluted acids.

Therapeutic Function

Spasmolytic