Tixocortol
- Product Name
- Tixocortol
- CAS No.
- 61951-99-3
- Chemical Name
- Tixocortol
- Synonyms
- Cortisol 21-Thiol;11β,17-Dihydroxy-21-Mercaptoprogesterone;(11β)-11,17-Dihydroxy-21-Mercaptopregn-4-ene-3,20-dione;Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-mercapto-, (11β)-
- CBNumber
- CB81179943
- Molecular Formula
- C21H30O4S
- Formula Weight
- 378.53
- MOL File
- 61951-99-3.mol
N-Bromosuccinimide Price
- Product number
- T447490
- Product name
- Tixocortol
- Packaging
- 100mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- API0012677
- Product name
- TIXOCORTOL
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1963.5
- Updated
- 2021/12/16
- Product number
- 72683
- Product name
- Tixocortol
- Packaging
- 50mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- API0012677
- Product name
- TIXOCORTOL
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $750.75
- Updated
- 2021/12/16
Tixocortol Chemical Properties,Usage,Production
Originator
Pivalone,Jouveinal,France,1978
Uses
Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling.
Definition
ChEBI: A steroid sulfide in which the sulfanyl group is at C-21 of a polyoxygenated derivative of pregn-4-ene.
Manufacturing Process
In a reactor of 50 liters, sodium S-thiopivalate is prepared from 100 g of S_x0002_thiopivalic acid (0.844 mol), 214 cc of solution of sodium methylate, 3.95 M
(0.844 mol) in 25 liters of anhydrous acetone.
There are then added 285 g (0.603 mol) of dihydroxy-11β,17α-iodo-21-dioxo-
3,20-pregnene-4 and the mixture is brought up to the acetone reflux for two
hours. The solvent is eliminated by distillation under vacuum until there is
obtained a syrupy residue which is poured into 10 liters of iced water. The
insoluble part is filtered and dried under vacuum.
The crude product is purified by recrystallization from ethanol; weight: 250 g;
yield: 89.5%.
Therapeutic Function
Antiinflammatory