3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-

Product Name: 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-
CAS No.: 249503-25-1
Chemical Name: 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-
Synonyms: Immucillin-A;BCX4430 (freebase);GALIDESIVIR (BCX 4430);BCX4430 freebase (Galidesivir);(2S,3S,4R,5R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL;3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-
CBNumber: CB81211296
Molecular Formula: C11H15N5O3
Formula Weight: 265.27
MOL File: 249503-25-1.mol

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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- Property

Boiling point:: 661.2±55.0 °C(Predicted)
Density: 1.630±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 13.78±0.40(Predicted)
color: White to off-white
Water Solubility: Water : 1.53 mg/mL (5.77 mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16085
Product name: BCX4430
Purity: ≥98%
Packaging: 500μg
Price: $375
Updated: 2021/12/16

Cayman Chemical

Product number: 16085
Product name: BCX4430
Purity: ≥98%
Packaging: 1mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-3779
Product name: Galidesivir
Purity: 99.29%
Packaging: 1mg
Price: $600
Updated: 2021/12/16

AK Scientific

Product number: 7633CR
Product name: Galidesivir
Packaging: 1mg
Price: $910
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611929
Product name: BCX4430 freebase
Packaging: 5mg
Price: $2395.3
Updated: 2021/12/16

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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- Chemical Properties,Usage,Production

Uses

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3].

in vivo

Galidesivir (BCX4430) is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy^[1].
Galidesivir (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)^[4].

Animal Model:	Female Syrian golden hamsters (hamsters infected with YF virus)^[4]
Dosage:	4 mg/kg of body weight
Administration:	I.p.; twice daily for 7 days
Result:	Significantly improved the survival of hamsters infected with YFV.

References

[1] Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9(3):220-226. DOI:10.1016/j.jiph.2016.04.002
[2] Elfiky AA, et al. ICN-1229, Remdesivir, PSI-7977, Galidesivir, and GS 1278 against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. DOI:10.1016/j.lfs.2020.117592
[3] Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405. DOI:10.1038/nature13027
[4] Julander JG, et al. BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrob Agents Chemother. 2014;58(11):6607-6614. DOI:10.1128/AAC.03368-14

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)- Suppliers

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249503-25-1, 3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-Related Search:

3,4-Pyrrolidinediol, 2-(4-amino-5H-pyrrolo3,2-dpyrimidin-7-yl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-

BCX4430 (freebase)

(2S,3S,4R,5R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL

BCX4430 freebase (Galidesivir)

GALIDESIVIR (BCX 4430)

Immucillin-A

249503-25-1