Glufosinate-P Property

Melting point:

209-210 °C

Boiling point:

519.1±45.0 °C(Predicted)

alpha 

D25 +13.4° (c = 1 in water)

Density 

1.378±0.06 g/cm3(Predicted)

pka

2.22±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Glufosinate-P Chemical Properties,Usage,Production

Chemical Properties

A 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid that has S configuration at position 2. A glutamine synthetase inhibitor, it is used (generally as the corresponding ammonium or sodium salts, known as glufosinate-P-ammonium and glufosinate-P-sodium, respectively) as a herbicide to control annual weeds and grasses.

Definition

ChEBI: Glufosinate-P is a 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid that has S configuration at position 2. A glutamine synthetase inhibitor, it is used (generally as the corresponding ammonium or sodium salts, known as glufosinate-P-ammonium and glufosinate-P-sodium, respectively) as a herbicide to control annual weeds and grasses. It has a role as a herbicide, an EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor and an agrochemical. It is an enantiomer of a (2R)-glufosinate. It is a tautomer of a glufosinate-P zwitterion.

Biological Activity

Through oxidative stress C. elegans, racemic glufosinate-ammonium l-glufosinate-ammonium (Glufosinate-P) both mediated developmental toxicity (shortened developmental cycle, reduced body length width, promoted aging and decreased longevity), neurotoxicity (inhibited head swinging, body bending frequency acetylcholinesterase [AchE] activity) reproductive toxicity (significant reductions in number eggs offspring in vivo induced apoptosis gonadal cells). The degradation rate of L-glufosinate-ammonium was faster than that of D-glufosinate-ammonium. Based on MDA content, protein content, and antioxidant enzyme (SOD CAT) activity, Meng et al. found that L-glufosinate-ammonium could cause more severe oxidative damage than rac-glufosinate-ammonium[1-2].

References

[1] Xu Zhao . “Comparison of the chronic and multigenerational toxicity of racemic glufosinate and l-glufosinate to Caenorhabditis elegans at environmental concentrations.” Chemosphere 316 (2023): Article 137863.
[2] Tianyou Feng. “Comparative analysis of toxicity and metabolomic profiling of rac-glufosinate and L-glufosinate in zebrafish.” Aquatic Toxicology 261 (2023): Article 106618.