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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE

Product Name
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
CAS No.
20231-01-0
Chemical Name
BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
Synonyms
EWP 815;4-methylpiperazino-thiuramdisulfide;4-METHYLPIPERAZINO-THIURAMDISULPHIDE;BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE;disulfide,bis((4-methyl-1-piperazinyl)thiocarbonyl);Bis(4-methyl-1-piperazinylthiocarbonyl) disulfide,98%;Piperazine, 1,1'-(dithiodicarbonothioyl)bis[4-methyl-;4-Methylpiperazine-1-carbothioic dithioperoxyanhydride
CBNumber
CB8121523
Molecular Formula
C12H22N4S4
Formula Weight
350.59
MOL File
20231-01-0.mol
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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Property

Melting point:
142-143 °C
Boiling point:
450.5±55.0 °C(Predicted)
Density 
1.339±0.06 g/cm3(Predicted)
pka
6.63±0.42(Predicted)
form 
Solid
color 
White to off-white
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Safety

Safety Statements 
24/25
HS Code 
29335995
Toxicity
LD50 oral in rat: > 5gm/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
TMT00676
Product name
4-Methylpiperazine-1-carbothioic dithioperoxyanhydride
Packaging
1G
Price
$550
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
CHM1042851
Product name
BIS-(4-METHYL-1-PIPERAZINYLTHIOCARBONYL)DISULFIDE
Purity
95.00%
Packaging
5MG
Price
$500.25
Updated
2021/12/16
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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2].

in vivo

EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice[2].

Animal Model:Female mice (20 g)[2]
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 30 min before killed
Result:Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3H-α-methyldopamine.
Reduced the amount of 3H-α-Me-NA by 12%.

References

[1] Fowler CJ, et al. Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):853-9. DOI:10.1042/bj2890853
[2] Carlsson A, et al. On the beta-hydroxylation of (+-)-alpha-methyldopamine in vivo. Eur J Pharmacol. 1968 Dec;5(1):85-92. DOI:10.1016/0014-2999(68)90160-x

BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE Suppliers

Belgium 1 China 12 Japan 1 United States 5 Global 19
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Thermo Fisher Scientific
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Tianjin Kailiqi Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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Shanghai Yifei Biotechnology Co. , Ltd.
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Shaoguan Qicheng Biotechnology Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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20231-01-0, BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDERelated Search:

Tetramethylthiuram Disulfide 1-Piperazinecarbodithioicacid,4-methyl-(6CI,8CI,9CI) BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE PICADEX Disulfiram

  • 4-methylpiperazino-thiuramdisulfide
  • disulfide,bis((4-methyl-1-piperazinyl)thiocarbonyl)
  • BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE
  • EWP 815
  • 4-METHYLPIPERAZINO-THIURAMDISULPHIDE
  • Bis(4-methyl-1-piperazinylthiocarbonyl) disulfide,98%
  • 4-Methylpiperazine-1-carbothioic dithioperoxyanhydride
  • Piperazine, 1,1'-(dithiodicarbonothioyl)bis[4-methyl-
  • 20231-01-0
  • C12H22N4S4