ChemicalBook > CAS DataBase List > (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride

(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride

Product Name
(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
CAS No.
137417-08-4
Chemical Name
(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
CBNumber
CB81216170
Molecular Formula
C17H18ClNO2
Formula Weight
303.79
MOL File
137417-08-4.mol
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(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride Property

storage temp. 
2-8°C
solubility 
Soluble to 10 mM in water and to 50 mM in DMSO
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0006766
Product name
Dihydrexidine(hydrochloride)
Purity
98.90%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0006766
Product name
Dihydrexidine(hydrochloride)
Purity
98.90%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0006766
Product name
Dihydrexidine(hydrochloride)
Purity
98.90%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0006766
Product name
Dihydrexidine(hydrochloride)
Purity
98.90%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride Chemical Properties,Usage,Production

Uses

Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5].

in vivo

Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
? Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

Animal Model:Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage:3 mg/kg
Administration:Intraperitoneal injection
Result:Produces prominent dopamine D1 receptor agonist effects in vivo.

IC 50

D1 Receptor: 10 nM (IC50)

storage

Desiccate at +4°C

References

[1] Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. DOI:10.1016/0014-2999(89)90690-0
[2] Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. PMID:1352553
[3] Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42. DOI:10.1111/j.1527-3458.2004.tb00024.x
[4] Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186(1), 25–31. DOI:10.1007/s00213-006-0342-2
[5] Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150(4):780-791. DOI:10.1016/j.cell.2012.06.037

(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride Suppliers

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137417-08-4, (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochlorideRelated Search:


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