ChemicalBook > CAS DataBase List > (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

Product Name
(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
CAS No.
136696-10-1
Chemical Name
(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
Synonyms
12-Oxo-ltb4;12-oxoleukotriene B4;12-Keto-leukotriene B4;12-dehydro-leukotriene B4;SJVWVCVZWMJXOK-NOJHDUNKSA-N;(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-
CBNumber
CB81235331
Molecular Formula
C20H30O4
Formula Weight
334.45
MOL File
136696-10-1.mol
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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Property

Boiling point:
524.2±50.0 °C(Predicted)
Density 
1.036±0.06 g/cm3(Predicted)
storage temp. 
Store at -80°C,protect from light
solubility 
DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml
pka
4.66±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
20140
Product name
12-oxo Leukotriene B4
Purity
≥90%
Packaging
25μg
Price
$222
Updated
2024/03/01
Cayman Chemical
Product number
20140
Product name
12-oxo Leukotriene B4
Purity
≥90%
Packaging
50μg
Price
$414
Updated
2024/03/01
Cayman Chemical
Product number
20140
Product name
12-oxo Leukotriene B4
Packaging
10μg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
20140
Product name
12-oxo Leukotriene B4
Purity
≥90%
Packaging
100μg
Price
$723
Updated
2024/03/01
TRC
Product number
L330410
Product name
12-OxoleukotrieneB4inacetonitrile
Packaging
50μL
Price
$380
Updated
2021/12/16
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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Chemical Properties,Usage,Production

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.

Uses

12-oxo Leukotriene B4 in acetonitrile is a potent eicosanoid lipid mediators.

Definition

ChEBI: A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Suppliers

China 7 United States 2 Global 9
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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sales@chemegen.com
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Energy Chemical
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Shanghai Yiyan Biotechnology Co. , Ltd.
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021-69985186 13611928337
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Shanghai Yifei Biotechnology Co. , Ltd.
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TargetMol Chemicals Inc.
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136696-10-1, (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acidRelated Search:

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid 2,4-HEPTADIEN-6-ONE

  • (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
  • 12-Keto-leukotriene B4
  • 12-oxoleukotriene B4
  • 12-Oxo-ltb4
  • 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-
  • 12-dehydro-leukotriene B4
  • SJVWVCVZWMJXOK-NOJHDUNKSA-N
  • 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-
  • 136696-10-1