[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid

Product Name: [hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid
CAS No.: 491-97-4
Chemical Name: [hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid
Synonyms: 5'-TDP;Deoxy-tdp;Thymidine Impurity 4;Tirofiban Impurity 74;Thymidine diphosphate;Thymidine pyrophosphate;Thymidine 5'-pyrophosphate;2'-Deoxythymidine 5'-diphosphate;Thymidine 5'-(trihydrogen diphosphate);Thymidine 5'-(trihydrogen diphosphate) (9ci)
CBNumber: CB81235881
Molecular Formula: C10H16N2O11P2
Formula Weight: 402.19
MOL File: 491-97-4.mol

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[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid Property

Density: 1.804±0.06 g/cm3(Predicted)
pka: 1.04±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid Chemical Properties,Usage,Production

Uses

Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2].

Definition

ChEBI: A thymidine phosphate having a diphosphate group at the 5'-position.

IC 50

Human Endogenous Metabolite

References

[1] Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. DOI:10.2174/0929867311320100006
[2] Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30. DOI:10.1002/elps.200410091

[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid Suppliers

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491-97-4, [hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acidRelated Search:

5'-TDP

Thymidine 5'-pyrophosphate

Thymidine diphosphate

Thymidine pyrophosphate

Deoxy-tdp

Thymidine 5'-(trihydrogen diphosphate) (9ci)

[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid

Thymidine 5'-(trihydrogen diphosphate)

2'-Deoxythymidine 5'-diphosphate

Tirofiban Impurity 74

Thymidine Impurity 4

491-97-4

C10H16N2O11P2