ChemicalBook > CAS DataBase List > 3-CHLORO-5-METHOXY-BENZOIC ACID

3-CHLORO-5-METHOXY-BENZOIC ACID

Product Name: 3-CHLORO-5-METHOXY-BENZOIC ACID
CAS No.: 82477-67-6
Chemical Name: 3-CHLORO-5-METHOXY-BENZOIC ACID
Synonyms: Benzoicacid,3-chloro-5-Methoxy;3-CHLORO-5-METHOXY-BENZOIC ACID;3-Chloro-5-methoxybenzoic acid 97%;3-Chloro-5-methoxy-benzoic acid≥ 97% (GC);3-Carboxy-5-chloroanisole, 5-Chloro-m-anisic acid
CBNumber: CB8125132
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 82477-67-6.mol

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3-CHLORO-5-METHOXY-BENZOIC ACID Property

Melting point:: 172-176 °C
Boiling point:: 323.1±22.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder
pka: 3.71±0.10(Predicted)
color: Off white (hint of dark cream & peach)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696374
Product name: 3-Chloro-5-methoxybenzoic acid
Purity: 97%
Packaging: 1g
Price: $70.4
Updated: 2023/06/20

Sigma-Aldrich

Product number: 696374
Product name: 3-Chloro-5-methoxybenzoic acid
Purity: 97%
Packaging: 5g
Price: $145
Updated: 2023/06/20

TRC

Product number: C367513
Product name: 3-Chloro-5-methoxybenzoic acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: C367513
Product name: 3-Chloro-5-methoxybenzoic acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C367513
Product name: 3-Chloro-5-methoxybenzoic acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

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3-CHLORO-5-METHOXY-BENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

3-chloro-5-methoxybenzoic acid

Synthesis

124-38-9

33719-74-3

82477-67-6

The general procedure for the synthesis of 3-chloro-5-methoxybenzoic acid from carbon dioxide and 3,5-dichloroanisole is as follows: the magnesium scraps (Fluka purum used for the Grignard reaction) are first pre-treated: the scraps are placed in a glass sintered funnel, 0.1 M hydrochloric acid is added and stirred with a glass rod for a few seconds, followed by a wash with three parts water to remove the acid. Finally, the magnesium chips were washed with two parts of acetone and bottled. Next, RedAl (1 g, 70% wt. of toluene solution) was added to dry tetrahydrofuran (100 mL, 99.95%) for drying. Pretreated magnesium shavings (5 g, 200 mmol) were placed in a round-bottomed flask and rinsed three times with nitrogen. 3,5-Dichloroanisole (26 g, 146 mmol) was dissolved in dry tetrahydrofuran (100 mL) and dibromoethane (1.8 g, 10 mmol) was added. The reaction mixture was flushed with nitrogen and refluxed for 2 hours. The heating was stopped and dry ice (10 g) was added in batches over 2 min. After all the dry ice was dissolved, the reaction mixture was poured into ice containing 2 M hydrochloric acid (400 mL). Post-treatment by ether (300 mL) extraction resulted in 11.2 g of 3-chloro-5-methoxybenzoic acid, 60.2 mmol in 41% yield.1H-NMR (500 MHz; acetone-d6): δ 7.57 (m, 1H), 7.49 (m, 1H), 7.23 (m, 1H), 3.91 (s, 3H).

References

[1] Patent: WO2003/101956, 2003, A1. Location in patent: Page 55
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 5, p. 577 - 585

3-CHLORO-5-METHOXY-BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-5-METHOXY-BENZOIC ACID manufacturers

Career Henan Chemical Co

Product: 3-CHLORO-5-METHOXY-BENZOIC ACID 82477-67-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

82477-67-6, 3-CHLORO-5-METHOXY-BENZOIC ACIDRelated Search:

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3-CHLORO-5-METHOXY-BENZOIC ACID

3-Carboxy-5-chloroanisole, 5-Chloro-m-anisic acid

Benzoicacid,3-chloro-5-Methoxy

3-Chloro-5-methoxybenzoic acid 97%

3-Chloro-5-methoxy-benzoic acid≥ 97% (GC)

82477-67-6

Carboxylic Acids

Phenyls & Phenyl-Het

Carbonyl Compounds