ChemicalBook > CAS DataBase List > 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE

2-METHOXY-4,6-DIMETHYLNICOTINONITRILE

Product Name
2-METHOXY-4,6-DIMETHYLNICOTINONITRILE
CAS No.
65515-39-1
Chemical Name
2-METHOXY-4,6-DIMETHYLNICOTINONITRILE
Synonyms
2-METHOXY-4,6-DIMETHYLNICOTINONITRILE;2-Methoxy-3-cyano-4,6-diMethylpyridine;3-Cyano-2-Methoxy-4,6-diMethylpyridine;2-methoxy-4,6-dimethylpyridine-3-carbonitrile;3-Pyridinecarbonitrile, 2-methoxy-4,6-dimethyl-;3-Cyano-4,6-dimethyl-2-methoxypyridine, 2-Methoxy-4,6-dimethylpyridine-3-carbonitrile
CBNumber
CB81253454
Molecular Formula
C9H10N2O
Formula Weight
162.19
MOL File
65515-39-1.mol
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2-METHOXY-4,6-DIMETHYLNICOTINONITRILE Property

Melting point:
282-284℃
Boiling point:
294.0±35.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
1.32±0.18(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M269735
Product name
2-Methoxy-4,6-dimethylnicotinonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
046661
Product name
2-Methoxy-4,6-dimethylnicotinonitrile
Purity
>95%
Packaging
5g
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
046661
Product name
2-Methoxy-4,6-dimethylnicotinonitrile
Purity
>95%
Packaging
25g
Price
$370
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0008980
Product name
2-METHOXY-4,6-DIMETHYL NICOTINONITRILE
Purity
95.00%
Packaging
1G
Price
$692.46
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0008980
Product name
2-METHOXY-4,6-DIMETHYL NICOTINONITRILE
Purity
95.00%
Packaging
2.5G
Price
$932.6
Updated
2021/12/16
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2-METHOXY-4,6-DIMETHYLNICOTINONITRILE Chemical Properties,Usage,Production

Synthesis

14237-71-9

124-41-4

65515-39-1

General procedure for the synthesis of 2-methoxy-4,6-dimethylnicotinonitrile from 2-chloro-3-cyano-4,6-dimethylpyridine and sodium methanol: A methanolic solution of sodium methanol (30 mass %, 175 mL, 940 mmol) was added slowly and dropwise to a methanolic solution (450 mL) of 2-chloro-4,6-dimethylpyridine-3-carbonitrile (75 g, 441.1 mmol) The reaction was carried out in a water bath. Subsequently, a methanolic solution of sodium methanolate (25 mass %, 250 mL, 1090 mmol) was added dropwise. The reaction mixture was stirred for 1 hour and then poured into ice water and continued to stir for 30 minutes and the solid product was collected by filtration. The filter cake was washed with hexane and dried in a vacuum oven overnight. The aqueous phase filtrate was extracted with dichloromethane and the organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The solid obtained by filtration was combined with the concentrated residue to give 2-methoxy-4,6-dimethylnicotinonitrile as a solid product (71.8 g, quantitative yield). Electrospray mass spectrometry (ES/MS) showed m/z: 163 ([M+H]+).

References

[1] Patent: WO2017/35060, 2017, A1. Location in patent: Page/Page column 48; 49
[2] Patent: WO2005/63768, 2005, A1. Location in patent: Page/Page column 33-34
[3] Patent: WO2005/97750, 2005, A1. Location in patent: Page/Page column 75
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 331

2-METHOXY-4,6-DIMETHYLNICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE manufacturers

Career Henan Chemical Co
Product
2-METHOXY-4,6-DIMETHYLNICOTINONITRILE 65515-39-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

65515-39-1, 2-METHOXY-4,6-DIMETHYLNICOTINONITRILERelated Search:

3-Cyano-2-methoxy-4,6-diphenylpyridine 3-Cyano-2-ethoxy-4,6-diphenylpyridine 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE SALOR-INT L152781-1EA SALOR-INT L152927-1EA 2-(4-METHOXYPHENOXY)-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE 4-(4-CHLOROPHENYL)-2-(4-FLUOROPHENOXY)-6-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE SALOR-INT L152730-1EA 6-METHYL-4-(TRIFLUOROMETHYL)-2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINONITRILE BUTTPARK 104\40-64 SALOR-INT L152986-1EA SALOR-INT L152943-1EA N-[3-((4-(4-CHLOROPHENYL)-3-CYANO-6-[3-(TRIFLUOROMETHYL)PHENYL]-2-PYRIDINYL)OXY)PHENYL]ACETAMIDE 2-(4-CHLOROPHENOXY)-4-(4-CHLOROPHENYL)-6-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE 3-CYANO-4,6-DIMETHYL-2-PYRIDINYL 2,4,6-TRICHLOROBENZENECARBOXYLATE 4-(2,4-DICHLOROPHENYL)-2-(4-METHOXYPHENOXY)-6-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE SALOR-INT L152978-1EA 2-PHENOXY-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE

  • 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE
  • 2-Methoxy-3-cyano-4,6-diMethylpyridine
  • 3-Cyano-4,6-dimethyl-2-methoxypyridine, 2-Methoxy-4,6-dimethylpyridine-3-carbonitrile
  • 3-Cyano-2-Methoxy-4,6-diMethylpyridine
  • 2-methoxy-4,6-dimethylpyridine-3-carbonitrile
  • 3-Pyridinecarbonitrile, 2-methoxy-4,6-dimethyl-
  • 65515-39-1
  • 64415-39-1
  • cyanide
  • Pyridines