2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected
- Product Name
- 2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected
- CAS No.
- 243972-26-1
- Chemical Name
- 2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected
- Synonyms
- SKL1091;2-AMino-5-(tributylstannyl)-1,3-thiazole;2-(Boc-amino)-5-(tributylstannyl)thiazole;2-(N-Boc-amino)-5-(tributylstannyl)thiazole;2-(N-BOC)-5-(tributylstannyl)thiazole - [B2263];2-(N-Boc-amino)-5-(tributylstannyl)thiazole;2-Amino-5-(tributylstannyl)-1,3-thiazole, 2-BOC protected;2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected;tert-butyl N-(5-tributylstannyl-1,3-thiazol-2-yl)carbamate;tert-butyl N-(5-tributylstannyl-1,3-thiazol-2-yl)carbamatepp
- CBNumber
- CB81262410
- Molecular Formula
- C20H38N2O2SSn
- Formula Weight
- 489.3
- MOL File
- 243972-26-1.mol
2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected Property
- Melting point:
- 78-86°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 5.24±0.70(Predicted)
- Appearance
- White to off-white Solid
- InChI
- 1S/C8H11N2O2S.3C4H9.Sn/c1-8(2,3)12-7(11)10-6-9-4-5-13-6;3*1-3-4-2;/h4H,1-3H3,(H,9,10,11);3*1,3-4H2,2H3;
- InChIKey
- WBQYLGCBVADFPD-UHFFFAOYSA-N
- SMILES
- CCCC[Sn](CCCC)(CCCC)c1cnc(NC(=O)OC(C)(C)C)s1
Safety
- Hazard Codes
- T,N
- Risk Statements
- 21-25-36/38-48/23/25-50/53
- Safety Statements
- 36/37/39-45-60-61
- RIDADR
- UN 3146 6.1 / PGIII
- WGK Germany
- 3
- HS Code
- 2934100090
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2
STOT RE 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 729256
- Product name
- 2-(N-Boc-amino)-5-(tributylstannyl)thiazole
- Packaging
- 1g
- Price
- $388
- Updated
- 2023/01/07
- Product number
- 729256
- Product name
- 2-(N-Boc-amino)-5-(tributylstannyl)thiazole
- Packaging
- 5g
- Price
- $1520
- Updated
- 2023/01/07
- Product number
- 729256
- Product name
- 2-(N-Boc-amino)-5-(tributylstannyl)thiazole
- Packaging
- 500mg
- Price
- $206
- Updated
- 2023/01/07
- Product number
- B663290
- Product name
- 2-(N-Boc)-5-(Tributylstannyl)thiazole
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 9H50-1-X6
- Product name
- 2-Amino-5-(tributylstannyl)-1,3-thiazole, 2-Boc protected
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected Chemical Properties,Usage,Production
Synthesis
1461-22-9
170961-15-6
243972-26-1
Step 2: tert-butyl thiazole-2-carbamate (1.0 g, 5.0 mmol) was dissolved in tetrahydrofuran (THF) and cooled to -78 °C. To this solution, freshly prepared lithium diisopropylammonium (LDA, 2.1 eq.) was slowly added and the reaction mixture was stirred at this temperature for 1 hour. Subsequently, tributyltin chloride (1.62 g, 5.0 mmol) was added dropwise and stirring was continued at -78 °C for 24 hours. Upon completion of the reaction, the reaction was quenched by the addition of 100 mL of saturated aqueous ammonium chloride (NH4Cl) and extracted with ethyl acetate (EtOAc, 3 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford tert-butyl (5-(tributylstannyl)thiazol-2-yl)carbamate as a brown solid (2.25 g, 92% yield). Electrospray ionization mass spectrometry (ESIMS): m/z 491 ([M+H]+).
References
[1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 121; 122
[2] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 65; 66
2-Amino-5-(tributylstannyl)-1,3-thiazole, N-BOC protected Preparation Products And Raw materials
Raw materials
Preparation Products
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