2-Pyridinemethanol,5-chloro-(9CI)
- Product Name
- 2-Pyridinemethanol,5-chloro-(9CI)
- CAS No.
- 209526-98-7
- Chemical Name
- 2-Pyridinemethanol,5-chloro-(9CI)
- Synonyms
- (5-CHLOROPYRIDIN-2-YL)METHANOL;5-chloro-2-PyridineMethanol;(5-Chloro-2-pyridyl)methanol;2-Pyridinemethanol, 5-chloro-;2-Pyridinemethanol,5-chloro-(9CI);5-Chloro-2-(hydroxymethyl)pyridine;(5-Chloropyridin-2-yl)methanol, 5-Chloropicolinyl alcohol
- CBNumber
- CB81275106
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 209526-98-7.mol
2-Pyridinemethanol,5-chloro-(9CI) Property
- Melting point:
- 45～47℃
- Boiling point:
- 234.9±25.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 13.12±0.10(Predicted)
- color
- Grey
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B405160
- Product name
- (5-Chloropyridin-2-yl)methanol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B405160
- Product name
- (5-Chloropyridin-2-yl)methanol
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 046962
- Product name
- (5-Chloro-2-pyridinyl)methanol
- Purity
- >95%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- FC54492
- Product name
- 5-Chloro-2-(hydroxymethyl)pyridine
- Packaging
- 250mg
- Price
- $72.5
- Updated
- 2021/12/16
- Product number
- OR16865
- Product name
- 5-Chloro-2-(hydroxymethyl)pyridine
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
2-Pyridinemethanol,5-chloro-(9CI) Chemical Properties,Usage,Production
Synthesis
132308-19-1
209526-98-7
General procedure for the synthesis of (5-chloro-2-pyridyl)methanol from methyl 5-chloropyridine-2-carboxylate: 1. Synthesis of intermediate 2: (5-chloro-2-pyridyl)methanol - Methyl 5-chloro-2-pyridinecarboxylate (43 g, 251 mmol) was dissolved in methanol (400 mL) at 0 °C. - NaBH4 (28.7 g, 754 mmol) was added to the above solution in small portions over about 30 min. - After addition, the reaction mixture was stirred at room temperature for 2 h. The completion of the reaction was confirmed by TLC analysis. - After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was adjusted to pH 1 with 1N HCl. - The resulting solution was extracted with EtOAc (3 x 300 mL) and the organic layers were combined. - The organic layer was dried with Na2SO4 and the solvent was evaporated. - The residue was purified by silica gel column chromatography using 10:1 petroleum ether/EtOAc as eluent to afford the title compound (5-chloro-2-pyridyl)methanol (36 g, 99%). Product Characterization: 1H NMR (1H NMR). - Product characterization: 1H NMR (400 MHz, CDCl3) δ ppm 8.44 (d, J = 1.60 Hz, 1H), 7.62 (dd, J = 8.40, 2.40 Hz, 1H), 7.25 (d, J = 8.40 Hz, 1H), 4.69 (s, 2H), 3.83 (s, 1H).
References
[1] Patent: WO2009/76387, 2009, A1. Location in patent: Page/Page column 27
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2010/141539, 2010, A1. Location in patent: Page/Page column 18-19
[4] Patent: WO2010/141545, 2010, A1. Location in patent: Page/Page column 19-20
[5] Patent: WO2010/141540, 2010, A1. Location in patent: Page/Page column 17-18
2-Pyridinemethanol,5-chloro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Pyridinemethanol,5-chloro-(9CI) manufacturers
- Product
- 2-Pyridinemethanol,5-chloro-(9CI) 209526-98-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-20