ChemicalBook > CAS DataBase List > 2-Pyridinemethanamine,5-fluoro-(9CI)

2-Pyridinemethanamine,5-fluoro-(9CI)

Product Name: 2-Pyridinemethanamine,5-fluoro-(9CI)
CAS No.: 561297-96-9
Chemical Name: 2-Pyridinemethanamine,5-fluoro-(9CI)
Synonyms: 5-Fluoro-2-pyridinemethanamine;(5-fluoro-2-pyridyl)methanamine;2-(AMinoMethyl)-5-fluoropyridine;2-Pyridinemethanamine, 5-fluoro-;5-fluoro-(9CI)2-Pyridinemethanamine;2-Pyridinemethanamine,5-fluoro-(9CI);C-(5-Fluoro-pyridin-2-yl)-MethylaMine;(5-fluoro-2-pyridyl)methanamine - [F86980];1-(5-FLUOROPYRIDIN-2-YL)METHANAMINE HYDROCHLORIDE
CBNumber: CB81284586
Molecular Formula: C6H7FN2
Formula Weight: 126.13
MOL File: 561297-96-9.mol

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2-Pyridinemethanamine,5-fluoro-(9CI) Property

Boiling point:: 181.6±25.0 °C(Predicted)
Density: 1.180±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 8.30±0.39(Predicted)
form: liquid
color: Colourless

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F600110
Product name: (5-Fluoropyridin-2-yl)methanamine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC403119
Product name: (5-Fluoropyridin-2-yl)methanamine
Purity: 95%
Packaging: 250mg
Price: $81
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-3S
Product name: (5-Fluoropyridin-2-yl)methanamine
Purity: 95%
Packaging: 250mg
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0101752
Product name: 1-(5-FLUOROPYRIDIN-2-YL)METHANAMINE
Purity: 95.00%
Packaging: 5MG
Price: $497.39
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0063262
Product name: 1-(5-FLUOROPYRIDIN-2-YL)METHANAMINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $497.88
Updated: 2021/12/16

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2-Pyridinemethanamine,5-fluoro-(9CI) Chemical Properties,Usage,Production

Synthesis

327056-62-2

561297-96-9

General procedure for the synthesis of 5-fluoropyridine-2-methylamine from 2-cyano-5-fluoropyridine: 1. hydrogenation reaction: 2-cyano-5-fluoropyridine (63.2 g, 0.52 mol), nickel ruanne (22.5 g) and ammonia-saturated ethanol (1.5 L) were mixed and reacted at 70°C for 16 hours under 500 psi hydrogen pressure. 2. Purification: After completion of the reaction, the dark purple liquid was separated by fast silica gel column chromatography (eluent: dichloromethane/methanol/ammonium hydroxide = 95:4.5:0.5). Concentration gave the free base of 5-fluoropyridine-2-methylamine in yellow liquid in a yield of 25.0 g (44%). Characterization data: 1H NMR (DMSO-d6) δ 8.43 (d, J=2.9Hz, 1H), 7.66 (m, 1H), 7.50 (m, 1H), 3.77 (s, 2H), 2.10 (br, 2H); MS (ESI) m/z 127 (M+H). 3. Salt-forming reaction: the free base (20.0 g, 159.0 mmol) was dissolved in 1,4-dioxane (150 mL) and a dioxane solution (150 mL, 3.8 eq.) of 4N HCl was added to immediately precipitate a white solid. It was diluted with ether (300 mL) and filtered to give 5-fluoropyridine-2-methylamine dihydrochloride. 4. Drying: The product was dried at 20 mmHg, 60°C to give pure dihydrochloride in a yield of 30.0 g (95%). Characterization data: 1H NMR (DMSO-d6) δ 8.61 (d, J=2.9Hz, 1H), 8.50 (brs, 3H), 7.82 (m, 1H), 7.62 (m, 1H), 7.50 (br, 1H), 4.18 (m, 2H); MS (ESI) m/z 127 (M+H, free base).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2006/12374, 2006, A1. Location in patent: Page/Page column 214
[3] Patent: US2003/225106, 2003, A1. Location in patent: Page 95
[4] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 108; 109
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2793 - 2800

2-Pyridinemethanamine,5-fluoro-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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