4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI)
- Product Name
- 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI)
- CAS No.
- 133046-46-5
- Chemical Name
- 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI)
- Synonyms
- Ethyl 2-(Trifluoromethyl)-1,3-Thiazole-4-Carboxylate;2-TrifluoroMethyl-thiazole-4-carboxylic acid ethyl ester;4-Thiazolecarboxylicacid,2-(trifluoroMethyl)-,ethylester;4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI)
- CBNumber
- CB81293012
- Molecular Formula
- C7H6F3NO2S
- Formula Weight
- 225.19
- MOL File
- 133046-46-5.mol
4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) Property
- Melting point:
- 49-50°
- Boiling point:
- 194.8±40.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.54±0.10(Predicted)
- Appearance
- White to yellow <49°C Solid,>50°C Liquid
Safety
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E930608
- Product name
- Ethyl2-(Trifluoromethyl)thiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- X9845
- Product name
- Ethyl2-(trifluoromethyl)thiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $102
- Updated
- 2021/12/16
- Product number
- PC401006
- Product name
- Ethyl2-(trifluoromethyl)thiazole-4-carboxylate
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 8H23-3-07
- Product name
- Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- 059060
- Product name
- Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate
- Purity
- 95%+
- Packaging
- 1g
- Price
- $259
- Updated
- 2021/12/16
4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) Chemical Properties,Usage,Production
Synthesis
354-38-1
70-23-5
133046-46-5
The general procedure for the synthesis of ethyl 2-trifluoromethyl-4-carboxylate thiazole from trifluoroacetamide and ethyl 3-bromopyruvate was as follows: 2,2,2-trifluoroacetamide (14.24 g, 1 eq.) and Lawesson's reagent (30.6 g, 0.6 eq.) were dissolved in THF (120 mL), and the reaction was stirred for 18 hr. under reflux conditions. Upon completion of the reaction, the mixture was cooled, ethyl 3-bromopyruvate (16 mL, 1 eq.) was added, and the reaction was continued under reflux conditions until the end of the week. At the end of the reaction, the reaction mixture was cooled, the solvent was evaporated under vacuum and the crude product obtained was extracted with dichloromethane and washed with water. The organic layer was dried with anhydrous Na2SO4, filtered and concentrated to give an orange colored oil. Purification of the above oil by silica gel column chromatography (eluent: petroleum ether/dichloromethane) afforded the target compound 251 in 40% yield.1H NMR (DMSO-d6, 400 MHz): δ (ppm) 1.32 (t, J = 7.10 Hz, 3H), 4.34 (q, J = 7.10 Hz, 2H), 8.9 (s, 1H); 19F NMR (DMSO-d6, 376 MHz): δ (ppm) -60.29 (s, 3F); MS (ESI, EI+): m/z = 225.9 (MH+).
References
[1] Patent: WO2011/17389, 2011, A1. Location in patent: Page/Page column 161-162
[2] Patent: WO2013/163279, 2013, A1. Location in patent: Paragraph 00141
[3] Patent: US2015/18328, 2015, A1. Location in patent: Paragraph 1206
[4] Patent: WO2015/3640, 2015, A1. Location in patent: Page/Page column 265
4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) manufacturers
- Product
- 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) 133046-46-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) 133046-46-5
- Price
- US $19.00/Kg/Bag
- Min. Order
- 25Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-13
- Product
- 4-Thiazolecarboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) 133046-46-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 10kg; 100kg
- Release date
- 2019-08-30