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DICHLORPHENAMIDE

Product Name
DICHLORPHENAMIDE
CAS No.
120-97-8
Chemical Name
DICHLORPHENAMIDE
Synonyms
cb8000;CB 8000;Glaucor;Oralcon;glaucol;Oratrol;Dalanide;daramide;Daranide;Dasanide
CBNumber
CB8129776
Molecular Formula
C6H6Cl2N2O4S2
Formula Weight
305.16
MOL File
120-97-8.mol
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DICHLORPHENAMIDE Property

Melting point:
239-241° (patent, mp 228.5-229°)
Boiling point:
590.5±60.0 °C(Predicted)
Density 
1.7263 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Acetonitrile (Slightly), Chloroform, DMSO (Slightly), Methanol
form 
Solid
pka
pKa 7.4 (Uncertain);8.6 (Uncertain)
color 
White to Off-White
CAS DataBase Reference
120-97-8(CAS DataBase Reference)
NIST Chemistry Reference
4,5-Dichloro-m-benzenedisulfonamide(120-97-8)
EPA Substance Registry System
1,3-Benzenedisulfonamide, 4,5-dichloro- (120-97-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
63
Safety Statements 
36
RTECS 
CZ9200000
HS Code 
2935904000
Hazardous Substances Data
120-97-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1188006
Product name
Dichlorphenamide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
23658
Product name
Dichlorphenamide
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23658
Product name
Dichlorphenamide
Purity
≥98%
Packaging
10mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
23658
Product name
Dichlorphenamide
Packaging
25mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
23658
Product name
Dichlorphenamide
Packaging
50mg
Price
$172
Updated
2024/03/01
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DICHLORPHENAMIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Daranide,MSD ,US,1958

Uses

Like the drugs described above, dichlorphenamide is used for secreting excess water in cases of elevated intraocular pressure, and it is used for treating wide-angle and secondary glaucoma as well as in cases where it is necessary to lower intraocular pressure before surgical intervention in severe wide-angle glaucoma.

Uses

Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).

Definition

ChEBI: A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraoc lar pressure. It is used for the treatment of glaucoma.

Manufacturing Process

In a 2 liter round-bottomed flask equipped with stirrer and dropping funnel is placed 1,585 grams (880 cc; 13.6 mols) of chlorosulfonic acid. To this is added dropwise with stirring during 5 hours 218 grams (1.7 mols) of ochlorophenol. The mixture is allowed to stand 1 hour at room temperature and then is heated 1 hour on a steam bath. The mixture is then poured on ice.
A product consisting largely of 5-chloro-4-hydroxybenzene-1,3-disulfonyl chloride separates as a gum which solidifies on standing for about 1 hour. The solid product is collected on a Buchner funnel, washed with water and thoroughly dried in air at room temperature.
A mixture of this crude product (approximately 302 grams, 0.92 mol) and 480 grams (2.3 mols) of phosphorus pentachloride is heated for 1 hour at 120°- 140°C in a 2 liter round-bottomed flask. The resulting clear solution is poured on ice. 4,5-Dichlorobenzene-1,3-disulfonyl chloride separates immediately as a solid. It is collected by filtration and washed with water. While still moist, it is added in portions during about 20 minutes to 1 liter of concentrated ammonia water contained in a 3 liter beaker surrounded by a cold water bath. The reaction mixture is then allowed to stand for 1 hour without cooling after which it is heated on a steam bath for about 30 minutes while air is bubbled through it, in order to remove some of the excess ammonia. It is then filtered, acidified with concentrated hydrochloric acid and chilled.
The product separates as a gum from which the supernatant liquid is decanted, and the gum is triturated with 250 cc of water in order to induce crystallization. The crude product thus obtained is recrystallized from 3,200 cc of boiling water and then from 40% aqueous isopropyl alcohol yielding 4,5- dichlorobenzene-1,3-disulfonamide as a white solid, MP 228.5° to 229.0°C. of boiling water and then from 40% aqueous isopropyl alcohol yielding 4,5- dichlorobenzene-1,3-disulfonamide as a white solid, MP 228.5° to 229.0°C.

brand name

Daranide (Merck).

Therapeutic Function

Carbonic anhydrase inhibitor, Antiglaucoma

Clinical Use

Dichlorphenamide is a disulfonamide derivative that shares the same pharmacological properties。The dose of dichlorphenamide is 25 to 100 mg one to three times a day.

Synthesis

Dichlorphenamide, 4,5-dichlorbenzol-1,3-disulfonamide (21.2.6), is made in a relatively simple way from 2-chlorophenol. 2-Chlorophenol undergoes sulfochlorination by chlorosulfonic acid, forming 4-hydroxy-5-chlorobenzol-1,3- disulfonylchloride (21.2.4). The hydroxyl group is replaced by a chlorine atom using phosphorous pentachloride, giving 4,5-dichlorobenzol-1,3-disulfonylchoride (21.2.5), the reaction of which with ammonia gives the desired dichlorphenamide (21.2.6).

Veterinary Drugs and Treatments

Dichlorphenamide is used for the medical treatment of glaucoma. Because of availability issues and toxic effects associated with systemic therapy, human (and many veterinary) ophthalmologists are using topical carbonic anhydrase inhibitors (e.g., dorzolamide or brinzolamide) in place of acetazolamide, dichlorphenamide or methazolamide.

DICHLORPHENAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DICHLORPHENAMIDE Suppliers

Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5818
Advantage
50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from DICHLORPHENAMIDE manufacturers

Dideu Industries Group Limited
Product
DICHLORPHENAMIDE 120-97-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-08
Career Henan Chemical Co
Product
DICHLORPHENAMIDE 120-97-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
200KG
Release date
2020-01-07

120-97-8, DICHLORPHENAMIDERelated Search:


  • 1,3-Benzenedisulfonamide, 4,5-dichloro-
  • 1,3-disulfamoyl-4,5-dichlorobenzene
  • 1,3-Disulfamyl-4,5-dichlorobenzene
  • 3,4-Dichloro-5-sulfamylbenzenesulfonamide
  • 4,5-Dichloro-1,3-benzenedisulfonamide
  • 4,5-Dichloro-1,3-disulfamoylbenzene
  • 4,5-dichloro-3-benzenedisulfonamide
  • 4,5-Dichloro-m-benzendisulfonamide
  • 4,5-dichloro-m-benzenedisulfonamid
  • 4,5-dichloro-m-benzenedisulfonamide
  • 4,5-DICHLORO-META-BENZENEDISULFONAMIDE
  • 4,5-DICHLORO-BENZENE-1,3-DISULFONIC ACID DIAMIDE
  • 4,5-dichlorobenzene-1,3-disulphonamide
  • Dichlorfenamide
  • Antidrasi
  • CB 8000
  • LABOTEST-BB LT00771920
  • DICHLORPHENAMIDE
  • 4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE
  • Dalanide
  • Glaucor
  • Oralcon
  • Dichlophenamide
  • 4,5-dichloro-3-benzenedisulf
  • Dichlorphenamide (200 mg)
  • DiclofenaMid
  • Dichlorphenamide API
  • 4,5-dichloro-1,3-benzenedisolfonamide
  • cb8000
  • daramide
  • Daranide
  • Dasanide
  • dichlofenamid
  • Dichlofenamide
  • Dichlorophenamide
  • dichlorphenamid
  • Diclofenamide
  • glaucol
  • m-Benzenedisulfonamide, 4,5-dichloro-
  • Oratrol
  • DICHLORPHENAMIDE(DICLOFENAMIDE)
  • DICHLORPHENAMIDE USP/EP/BP
  • DiclofenamideQ: What is Diclofenamide Q: What is the CAS Number of Diclofenamide Q: What is the storage condition of Diclofenamide Q: What are the applications of Diclofenamide
  • Dichlorphenamide (1188006)
  • R)-(+)-Hydrobenzoin
  • Diclofenamide|||Daranide|||Antidrasi
  • 120-97-8
  • C6H6N2Cl2O4S2
  • C6H6Cl2N2O4S2
  • Inhibitors