lactosyl lysosphingolipid

Product Name: lactosyl lysosphingolipid
CAS No.: 109785-20-8
Chemical Name: lactosyl lysosphingolipid
Synonyms: Lactosyl-C18-sphingosine;lactosyl lysosphingolipid;lactosyl-beta-sphingosine;Lactosylsphingosine (d18:1);Lactosyl(β) Sphingosine (d18:1);Lactosyl(ss) Sphingosine (d18:1);Lyso-Lactosylceramide (synthetic);Lactosyl(beta) Sphingosine (d18:1);D-lactosyl-1-1'-D-erythro-sphingosine;D-lactosyl-?1-1'-D-erythro-sphingosine
CBNumber: CB81329335
Molecular Formula: C30H57NO12
Formula Weight: 623.77308
MOL File: 109785-20-8.mol

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lactosyl lysosphingolipid Property

Boiling point:: 845.8±65.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Chloroform:Methanol:Water (2:1:0.1): soluble; DMSO: soluble; Water: soluble
form: A solid
pka: 11.74±0.45(Predicted)
BRN: 5680460
InChIKey: MQKSCOKUMZMISB-VOCCQAPRSA-N
SMILES: OC1[C@@H](O)[C@H](OC[C@@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC)OC(CO)[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2

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Safety

WGK Germany: WGK 3
Storage Class: 13 - Non Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 42137
Product name: Lactosylsphingosine
Purity: ≥98.0% (TLC)
Packaging: 1mg
Price: $118
Updated: 2023/06/20

Sigma-Aldrich

Product number: 42137
Product name: Lactosylsphingosine
Purity: ≥98.0% (TLC)
Packaging: 5mg
Price: $468
Updated: 2023/06/20

Cayman Chemical

Product number: 24868
Product name: Lactosylsphingosine (d18:1)
Purity: ≥98%
Packaging: 1mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 24867
Product name: Lactosylsphingosine (d18:1) (synthetic)
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

TRC

Product number: L165310
Product name: Lactosyl-C18-sphingosine
Packaging: 2.5mg
Price: $205
Updated: 2021/12/16

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lactosyl lysosphingolipid Chemical Properties,Usage,Production

Description

Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside G_M3. [Matreya, LLC. Catalog No. 2088]

Uses

Lactosyl(β) Sphingosine (d18:1) or D-lactosyl-β1-1′-D-erythro-sphingosine has been used as an internal standard for the quantification of psychosineusing tandem mass spectrometry. It may be used to screen lipids that rapidly and reversibly altertransepithelialelectrical resistance (TER) or tight junction (TJ) permeability in epithelialtissue. It may also be used as a standard to determine the extent of recovery of lyso-neutral glycosphingolipids (lyso-n-GSLs) from the Sephadex column.

General Description

Lactosyl sphingosineis a glycosylsphingosine (Lyso-GSL), which is found in bovine brain white matter extract.

Biochem/physiol Actions

Lactosyl sphingosineexhibits better hemolytic activity than lysolecithin.

References

[1] S FIORE. Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils.[J]. Biochemical Journal, 1990, 266 1: 25-31. DOI: 10.1042/bj2660025
[2] SUMITA MISHRA Subroto C. Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes.[J]. Glycobiology, 2014, 24 6: 518-531. DOI: 10.1093/glycob/cwu020
[3] VIREAK THON. PmST2: a novel Pasteurella multocida glycolipid α2-3-sialyltransferase.[J]. Glycobiology, 2011, 21 9: 1206-1216. DOI: 10.1093/glycob/cwr054

lactosyl lysosphingolipid Preparation Products And Raw materials

Raw materials

Preparation Products

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lactosyl lysosphingolipid Suppliers

China 30 United Kingdom 1 United States 11 Global 42

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lactosyl lysosphingolipid

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109785-20-8

C30H57NO12