ChemicalBook > CAS DataBase List > 4-METHOXY-1H-INDAZOL-3-AMINE

4-METHOXY-1H-INDAZOL-3-AMINE

Product Name
4-METHOXY-1H-INDAZOL-3-AMINE
CAS No.
886362-07-8
Chemical Name
4-METHOXY-1H-INDAZOL-3-AMINE
Synonyms
4-methoxy-1H-indazol-4-amine;4-METHOXY-1H-INDAZOL-3-AMINE;1H-Indazol-3-aMine, 4-Methoxy-;4-Methoxy-1H-indazol-3-ylamine;4-(Methyloxy)-1H-indazol-3-amine;3-Amino-4-methoxy-1H-indazole 95%
CBNumber
CB8135645
Molecular Formula
C8H9N3O
Formula Weight
163.18
MOL File
886362-07-8.mol
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4-METHOXY-1H-INDAZOL-3-AMINE Property

Melting point:
85-87°C
Boiling point:
406.3±25.0 °C(Predicted)
Density 
1.344
pka
15.19±0.40(Predicted)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
755192
Product name
3-Amino-4-methoxy-1H-indazole
Purity
96%
Packaging
1g
Price
$66.5
Updated
2023/01/07
Alfa Aesar
Product number
H33750
Product name
3-Amino-4-methoxy-1H-indazole, 97%
Packaging
1g
Price
$166
Updated
2021/12/16
Alfa Aesar
Product number
H33750
Product name
3-Amino-4-methoxy-1H-indazole, 97%
Packaging
5g
Price
$555
Updated
2021/12/16
Alfa Aesar
Product number
H33750
Product name
3-Amino-4-methoxy-1H-indazole, 97%
Packaging
250mg
Price
$61
Updated
2021/12/16
Matrix Scientific
Product number
046012
Product name
4-Methoxy-1H-indazol-3-amine
Purity
>95%
Packaging
1g
Price
$63
Updated
2021/12/16
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4-METHOXY-1H-INDAZOL-3-AMINE Chemical Properties,Usage,Production

Uses

4-Methoxy-1H-indazol-3-amine is used as a reactant in the preparation and structure-activity relationship of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.

Synthesis


A mixture of 2-fluoro-6-(methyloxy)benzonitrile (8a) (10 g, 66 mmol) and hydrazine hydrate (9.63 mL, 198 mmol) in n-butanol (100 mL) was heated to reflux under nitrogen for 18 h. The reaction mixture was allowed to cool, water (300 mL) was added and the organic phase was removed. The solid in the aqueous phase was collected by filtration and dried in vacuo at 40 ??C to give a white solid (0.6 g). The butanol phase was evaporated in vacuo and the residue and the aqueous mother liquors were combined and extracted using ethyl acetate (2 ?á 200 mL). The combined ethyl acetate extractions were dried (MgSO4) and evaporated in vacuo. The residue was dissolved in DCM and applied to a 100 g silica cartridge. This was eluted with cyclohexane (500 mL), cyclohexane ethyl acetate (1:1, 500 mL) and ethyl acetate (500 mL). The required fractions were combined and evaporated in vacuo to give 9a (9.92 g, 92%) as an off-white solid. MS ES + ve m/z 164 (M + H)+. 1H NMR |? (DMSO-d6) 11.35 (1H, s), 7.10 (1H, t, J = 8 Hz), 6.76 (1H, d, J = 8 Hz), 6.29 (1H, d, J = 8 Hz), 4.95 (2H, br s), 3.85 (3H, s).

4-METHOXY-1H-INDAZOL-3-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-METHOXY-1H-INDAZOL-3-AMINE manufacturers

Career Henan Chemical Co
Product
4-METHOXY-1H-INDAZOL-3-AMINE 886362-07-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

886362-07-8, 4-METHOXY-1H-INDAZOL-3-AMINERelated Search:


  • 4-METHOXY-1H-INDAZOL-3-AMINE
  • 1H-Indazol-3-aMine, 4-Methoxy-
  • 4-(Methyloxy)-1H-indazol-3-amine
  • 4-Methoxy-1H-indazol-3-ylamine
  • 3-Amino-4-methoxy-1H-indazole 95%
  • 4-methoxy-1H-indazol-4-amine
  • 886362-07-8
  • Amines
  • Building Blocks
  • C8
  • Chemical Synthesis
  • Ethers
  • Nitrogen Compounds
  • Organic Building Blocks
  • Oxygen Compounds