songorine
- Product Name
- songorine
- CAS No.
- 509-24-0
- Chemical Name
- songorine
- Synonyms
- Songorin;Zongorine;Xuan-Wu 2;Bullatine;Napellonin;Napellonine;product/155133;ShiMoburo base I;Songorine,BullatineG;Bullatine G Songorine
- CBNumber
- CB81361634
- Molecular Formula
- C22H31NO3
- Formula Weight
- 357.49
- MOL File
- 509-24-0.mol
songorine Property
- Melting point:
- 201-203℃
- alpha
- D20 -135.4°
- Boiling point:
- 535.8±50.0 °C(Predicted)
- Density
- 1.29
- solubility
- DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 5 mg/ml; Ethanol: slightly soluble
- form
- A solid
- pka
- 14.20±0.60(Predicted)
- color
- White to off-white
Safety
- Toxicity
- LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0018585
- Product name
- Songorine
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0018585
- Product name
- Songorine
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FS145273
- Product name
- Songorine
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FS145273
- Product name
- Songorine
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FS145273
- Product name
- Songorine
- Packaging
- 50mg
- Price
- $400
- Updated
- 2021/12/16
songorine Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Chuanwu and Aconitum.
Uses
Songorine is an extract from the Aconitum flavum root and may act as an inhibitor of JNK and p53 enhancing stimulation of fibroblast colony/cluster formation and proliferative activity of mesosomal precursors.
in vivo
Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine?inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax[1]. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively[2].
songorine Preparation Products And Raw materials
Raw materials
Preparation Products
songorine Suppliers
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View Lastest Price from songorine manufacturers
- Product
- Songorine 509-24-0
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-02-26
- Product
- songorine 509-24-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30