norswertianolin
- Product Name
- norswertianolin
- CAS No.
- 54954-12-0
- Chemical Name
- norswertianolin
- Synonyms
- norswertianolin;9H-Xanthen-9-one, 8-(β-D-glucopyranosyloxy)-1,3,5-trihydroxy-;1,3,5-Trihydroxy-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9H-xanthen-9-one
- CBNumber
- CB81375059
- Molecular Formula
- C19H18O11
- Formula Weight
- 422.34
- MOL File
- 54954-12-0.mol
norswertianolin Property
- Melting point:
- 265 °C (decomp)
- Boiling point:
- 833.7±65.0 °C(Predicted)
- Density
- 1.789±0.06 g/cm3(Predicted)
- pka
- 6.73±0.20(Predicted)
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- PXT0002330
- Product name
- NORSWERTIANOLIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.47
- Updated
- 2021/12/16
norswertianolin Chemical Properties,Usage,Production
Uses
Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2].
Definition
ChEBI: A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and <ital Gentiana germanica.
in vivo
Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2].
| Animal Model: | Male Sprague Dawley rats (10~12 weeks)[2] |
| Dosage: | 4.4 mg/kg/day |
| Administration: | S.c. |
| Result: | Improved CSE/H2S production. |
References
[1] Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20. DOI:10.1155/2019/2692970
[2] Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212
norswertianolin Preparation Products And Raw materials
Raw materials
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