LG 50643
- Product Name
- LG 50643
- CAS No.
- 111372-42-0
- Chemical Name
- LG 50643
- Synonyms
- LG 50643
- CBNumber
- CB81384237
- Molecular Formula
- C24H34INO2
- Formula Weight
- 495.43673
- MOL File
- 111372-42-0.mol
LG 50643 Chemical Properties,Usage,Production
Description
LG 50643 is a muscarinic antagonist.
Uses
LG50643 is a potent and selective M3 muscarinic receptor antagonist (pKi=8.64).
in vivo
Three successive pre- and postjunctional responses were observed. The potencies (-logEC50) of (+/-)-LG50643 for pre- and postjunctional muscarinic receptors were determined and compared with those of selective muscarinic antagonists. In addition, the affinity values of (+/-)-LG50643 for muscarinic-receptor subtypes were determined in radioligand binding experiments in cerebral cortex, heart and salivary glands of rat as target tissues for M1, M2 and M3 receptors, respectively._x000D_ _x000D_ Reference: J Pharm Pharmacol. 1994 May;46(5):332-6. https://pubmed.ncbi.nlm.nih.gov/8083801/
target
LG 50643 is a muscarinic antagonist.
References
[1] D'AGOSTINO G, et al. Selectivity of LG50643 for Postjunctional Muscarinic‐receptor Subtype in the Guinea‐pig Trachea[J]. Journal of pharmacy and pharmacology, 1994, 46(5): 332-336. DOI:10.1111/j.2042-7158.1994.tb03807.x
LG 50643 Preparation Products And Raw materials
Raw materials
Preparation Products
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