2,6-dihydroxy-3-cyanopyridine
- Product Name
- 2,6-dihydroxy-3-cyanopyridine
- CAS No.
- 35441-10-2
- Chemical Name
- 2,6-dihydroxy-3-cyanopyridine
- Synonyms
- 2,6-dihydroxynicotinonitrile;2,6-dihydroxy-3-cyanopyridine;2-hydroxy-6-oxo-1H-pyridine-3-carbonitrile;2,6-dihydroxy-3-cyanopyridine ISO 9001：2015 REACH;6-Hydroxy-2-oxo-1,2-dihydropyridine-3-carbonitrile;2-hydroxy-6-oxo-1,6-dihydropyridine-3-carbonitrile;1,2-Dihydro-6-hydroxy-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-2-oxo-
- CBNumber
- CB81389308
- Molecular Formula
- C6H4N2O2
- Formula Weight
- 136.11
- MOL File
- 35441-10-2.mol
2,6-dihydroxy-3-cyanopyridine Property
- Melting point:
- 255 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 349.9±42.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.51±0.58(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- OR926143
- Product name
- 2,6-Dihydroxy-3-cyanopyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CHM0387908
- Product name
- 2,6-DIHYDROXY-3-CYANOPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.25
- Updated
- 2021/12/16
- Product number
- Y6194
- Product name
- 2,6-Dihydroxynicotinonitrile
- Packaging
- 50mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- OR926143
- Product name
- 2,6-Dihydroxy-3-cyanopyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- Y6194
- Product name
- 2,6-Dihydroxynicotinonitrile
- Packaging
- 5g
- Price
- $798
- Updated
- 2021/12/16
2,6-dihydroxy-3-cyanopyridine Chemical Properties,Usage,Production
Synthesis
91467-46-8
35441-10-2
In a 2000 L reaction flask, 160 g of 1,3-dibenzyluracil, 55.2 g of cyanoacetamide (1.2 eq.) and sodium methanol were added. Subsequently 2556.6 g (2.5 eq.) of liquid and 800 mL of methanol were added and stirring was initiated. The temperature of the reaction system was raised to 45-50 °C and the reaction was maintained at this temperature for 6 hours. The progress of the reaction was monitored by TLC and after confirming the completion of the reaction, the reaction solution was cooled to 20-30 °C, filtered and the filter cake was washed with 100 mL of methanol. The filter cake was transferred to a 2000 L reaction flask along with 800 g of water. After heating to 70-75 °C, the reaction solution was slowly cooled to 0-5 °C and kept at this temperature for 2 h. Subsequently, filtration was performed and the filter cake was washed with an appropriate amount of ice water to obtain 2,6-dihydroxynicotinonitrile monosodium salt dihydrate. The temperature was controlled at 20-30 °C and the filter cake was slowly added to an aqueous hydrochloric acid solution (prepared from 480 g of water and 66.6 g of concentrated hydrochloric acid). The crystallization was held at 20-30 °C for 1 h. The crystallization was continued to be cooled to 0-5 °C and kept for 2 h. The filtration was withdrawn and the filter cake was washed with an appropriate amount of ice water. After drying, 74.5 g of white solid 3-cyano-2,6-dihydroxypyridine was obtained in 86.5% yield. Its 1H NMR spectrum is shown in Figure 6.
References
[1] Patent: CN108341771, 2018, A. Location in patent: Paragraph 0056-0061
2,6-dihydroxy-3-cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-dihydroxy-3-cyanopyridine Suppliers
- Tel
- --
- Fax
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- akos@akosgmbh.eu
- Country
- Germany
- ProdList
- 1061
- Advantage
- 60
View Lastest Price from 2,6-dihydroxy-3-cyanopyridine manufacturers
- Product
- 2,6-dihydroxy-3-cyanopyridine 35441-10-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07
- Product
- 2,6-dihydroxy-3-cyanopyridine 35441-10-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25