CONESSINE
- Product Name
- CONESSINE
- CAS No.
- 546-06-5
- Chemical Name
- CONESSINE
- Synonyms
- NERIINE;NERVINE;CONESSIN;Konessin;CONESSINE;WRIGHTINE;ROQUESSINE;ROGUESSINE;NSC 119994;Conessinum
- CBNumber
- CB8139148
- Molecular Formula
- C24H40N2
- Formula Weight
- 356.59
- MOL File
- 546-06-5.mol
CONESSINE Property
- Melting point:
- 126-127°C
- alpha
- D20 +25.3° (c = 0.7 in abs alc)
- Boiling point:
- 479.38°C (rough estimate)
- Density
- 0.9492 (rough estimate)
- refractive index
- 1.5640 (estimate)
- storage temp.
- Store at RT
- solubility
- ethanol: ≥2mg/mL
- form
- powder
- pka
- 10.20±0.70(Predicted)
- color
- white to tan
- LogP
- 6.060 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0095
- Product name
- Conessine
- Purity
- ≥97% (HPLC)
- Packaging
- 10mg
- Price
- $53.4
- Updated
- 2024/03/01
- Product number
- SML0095
- Product name
- Conessine
- Purity
- ≥97% (HPLC)
- Packaging
- 50mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 11700
- Product name
- Conessine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 11700
- Product name
- Conessine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 11700
- Product name
- Conessine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $504
- Updated
- 2024/03/01
CONESSINE Chemical Properties,Usage,Production
Description
Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-
Uses
Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
Uses
antiamebic, antibacterial, antineoplastic, anesthetic (local)
Definition
ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
Biological Activity
Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
Purification Methods
It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
CONESSINE Preparation Products And Raw materials
Raw materials
Preparation Products
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