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CONESSINE

Product Name
CONESSINE
CAS No.
546-06-5
Chemical Name
CONESSINE
Synonyms
NERIINE;NERVINE;CONESSIN;Konessin;CONESSINE;WRIGHTINE;ROQUESSINE;ROGUESSINE;NSC 119994;Conessinum
CBNumber
CB8139148
Molecular Formula
C24H40N2
Formula Weight
356.59
MOL File
546-06-5.mol
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CONESSINE Property

Melting point:
126-127°C
alpha 
D20 +25.3° (c = 0.7 in abs alc)
Boiling point:
479.38°C (rough estimate)
Density 
0.9492 (rough estimate)
refractive index 
1.5640 (estimate)
storage temp. 
Store at RT
solubility 
ethanol: ≥2mg/mL
form 
powder
pka
10.20±0.70(Predicted)
color 
white to tan
optical activity
+25.320 (c 0.7, ethanol)
LogP
6.060 (est)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
GK7621000
HS Code 
2939799090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0095
Product name
Conessine
Purity
≥97% (HPLC)
Packaging
10mg
Price
$53.4
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0095
Product name
Conessine
Purity
≥97% (HPLC)
Packaging
50mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
11700
Product name
Conessine
Purity
≥98%
Packaging
50mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
11700
Product name
Conessine
Purity
≥98%
Packaging
100mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
11700
Product name
Conessine
Purity
≥98%
Packaging
250mg
Price
$504
Updated
2024/03/01
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CONESSINE Chemical Properties,Usage,Production

Description

Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4. Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.

Uses

Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.

Uses

antiamebic, antibacterial, antineoplastic, anesthetic (local)

Definition

ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.

Biological Activity

Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).

Purification Methods

It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]

CONESSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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546-06-5, CONESSINERelated Search:

(R)-2-Aminooctane N,N-Dimethyldodecylamine (S)-2-Aminooctane 1,12-Dodecanediamine CONESSINE CYCLOHEXANAMINE, 4-PENTYL- 1,7-HEPTANEDIOL 4-CYCLOHEXYL-BUTYLAMINE 2-Nonanamine levopropylhexedrine DIHEPTYLAMINE isotridecylamine 4-ETHYL-CYCLOHEXYLAMINE 1,11-DIAMINOUNDECANE CHEMBRDG-BB 4024867 2-(2-METHYL-CYCLOHEXYL)-ETHYLAMINE N-METHYLDIHEXYLAMINE 4,4-DIMETHYLCYCLOHEXYLAMINE

  • 3-beta-(dimethylamino)-con-5-enin
  • 3-beta-(dimethylamino)con-5-enine
  • n,18-dihydrotrimethyl-conkurchin
  • n-dimethyl-(3-beta)-con-5-enin-3-amin
  • WRIGHTINE
  • NERVINE
  • NERIINE
  • ROGUESSINE
  • ROQUESSINE
  • CONESSIN
  • CONESSINE
  • (3-BETA)-N,N-DIMETHYL-CON-5-ENIN-3-AMINE
  • 5-CONENIN-3BETA-DIMETHYLAMINE
  • CONESSINE(RG)
  • N,N-Dimethyl-con-5-enin-3-amine
  • CONESSINE(P)
  • (3β)-N,N-dimethyl-con-5-enin-3-amine
  • NSC 119994
  • Conessine (Wrightine Roguessine)
  • Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
  • Conessinum
  • Konessin
  • Con-5-enin-3-amine,N,N-dimethyl-, (3b)-
  • inhibit,Parasite,Inhibitor,malarial,infection,histamine H3 receptor,Conessine,Histamine Receptor
  • conessine ( or ) Neriine
  • 546-06-5
  • 546-06-7
  • C24H40N2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids