KB 5666
- Product Name
- KB 5666
- CAS No.
- 131916-69-3
- Chemical Name
- KB 5666
- Synonyms
- KB 5666
- CBNumber
- CB81392847
- Molecular Formula
- C24H32N4O5
- Formula Weight
- 456.53468
- MOL File
- 131916-69-3.mol
KB 5666 Chemical Properties,Usage,Production
Description
KB 5666 is a quinazoline derivative and lipid peroxidation inhibitor. Histologic, immunohistochemical and receptor-autoradiographic data indicate that KB-5666 protects the brain from both cellular and functional consequences of ischemia.
Uses
KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia[1].
References
[1] Prevention of hippocampus neuronal damage in ischemic gerbils by a novel lipid peroxidation inhibitor (quinazoline derivative) PMID:2243357
KB 5666 Preparation Products And Raw materials
Raw materials
Preparation Products
KB 5666 Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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- China
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- +17819995354
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