Atibeprone
- Product Name
- Atibeprone
- CAS No.
- 153420-96-3
- Chemical Name
- Atibeprone
- Synonyms
- Atibeprone;2H-1-Benzopyran-2-one, 3,4-dimethyl-7-[[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]methoxy]-
- CBNumber
- CB81401998
- Molecular Formula
- C17H18N2O3S
- Formula Weight
- 330.4
- MOL File
- 153420-96-3.mol
N-Bromosuccinimide Price
- Product number
- API0010742
- Product name
- ATIBEPRONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.88
- Updated
- 2021/12/16
Atibeprone Chemical Properties,Usage,Production
Originator
Atibeprone,BASF
Uses
Atibeprone (Lu 53439) is a selective MAO-B inhibitor. Atibeprone has antidepressant activity[1][2].
Manufacturing Process
10 mmol of 7-methoxy-3,4-dimethylcoumarin were stirred with 10 mmol (4.04 g) of Lawesson's reagent (2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4- diphosphetane 2,4-disulfide) in 20 ml of toluene at 90°C for 1-2.5 h. After cooling, the solvent was distilled off, the residue was taken up in DMF, and water was added. The precipitate was filtered off with suction and the crude 3,4-dimethyl-7-(2-isopropyl-1,3,4-thiadiazol-5-ylmethoxy)-2-thiocoumarin was purified by recrystallization from methanol or by column chromatography (silica gel, methylene chloride). Yield: 98%, melting point: 134-135°C.
Therapeutic Function
Antidepressant
References
[1] L?scher W,et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288(3):984-92. PMID:10027835
[2] Chhajed M, et al. Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells. Med Chem Res. 2014;23(6):3049-3064. DOI:10.1007/s00044-013-0890-z
Atibeprone Preparation Products And Raw materials
Raw materials
Preparation Products
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