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CHRYSOSPLENOLD

Product Name
CHRYSOSPLENOLD
CAS No.
14965-20-9
Chemical Name
CHRYSOSPLENOLD
Synonyms
Chrysosplel D;CHRYSOSPLENOLD;7-Methylaxillarin;Chrysosplenol D, 10 mM in DMSO;Quercetagetin 3,6,7-triMethyl ether;5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone;3,6,7-Trimethoxy-3',4',5-trihydroxyflavone;2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one;2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one;2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CBNumber
CB81404010
Molecular Formula
C18H16O8
Formula Weight
360.31
MOL File
14965-20-9.mol
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CHRYSOSPLENOLD Property

Melting point:
236-238 °C
Boiling point:
645.0±55.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
6.13±0.40(Predicted)
color 
Yellow
InChI
InChI=1S/C18H16O8/c1-23-12-7-11-13(14(21)17(12)24-2)15(22)18(25-3)16(26-11)8-4-5-9(19)10(20)6-8/h4-7,19-21H,1-3H3
InChIKey
BYWLLSQTJBXAPV-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(O)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1OC
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0245670
Product name
2-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-3,6,7-TRIMETHOXYCHROMEN-4-ONE
Purity
95.00%
Packaging
5MG
Price
$497.66
Updated
2021/12/16
Crysdot
Product number
CD32002372
Product name
ChrysosplenolD
Purity
95+%
Packaging
5mg
Price
$640
Updated
2021/12/16
Arctom
Product number
CFN99622
Product name
ChrysosplenolD
Packaging
10mg
Price
$268
Updated
2021/12/16
Arctom
Product number
AS030391
Product name
ChrysosplenolD
Purity
≥98%
Packaging
5mg
Price
$282
Updated
2021/12/16
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CHRYSOSPLENOLD Chemical Properties,Usage,Production

Uses

Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].

Definition

ChEBI: 3',4',5-trihydroxy-3,6,7-trimethoxyflavone is a trimethoxyflavone that is the 3,6,7-trimethyl ether derivative of quercetagetin. It has a role as an antineoplastic agent and a metabolite. It is a trihydroxyflavone and a trimethoxyflavone. It is functionally related to a quercetagetin.

in vivo

Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2].
Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4].
Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4].

References

[1] Habib ES, et, al. Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. Nat Prod Res. 2020 Aug 4;1-5. DOI:10.1080/14786419.2020.1802272
[2] Lang SJ, et, al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020 Jun 8;21(11):4090. DOI:10.3390/ijms21114090
[3] Skaf J, et, al. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018 Mar;125:191-198. DOI:10.1016/j.fitote.2017.11.001
[4] Li YJ, et, al. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8. DOI:10.1016/j.taap.2015.04.005

CHRYSOSPLENOLD Preparation Products And Raw materials

Raw materials

Preparation Products

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CHRYSOSPLENOLD Suppliers

China 77 United States 6 Global 83
Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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+86-21-20908456
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0871-65217109 13211707573;
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0871-65215563
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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021-38218169 13341702378
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Wuhan ChemFaces Biochemical Co., Ltd.
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14965-20-9, CHRYSOSPLENOLDRelated Search:

PONCIRIN Naringenin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers) hydroxygenkwanin 4',5-DIHYDROXY-7-METHOXYFLAVONE Quercetin-7-O-β-D-glucopyranoside MEDICAGOL MOSLOFLAVONE GARDENIN B

  • CHRYSOSPLENOLD
  • 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
  • 3,6,7-Trimethoxy-3',4',5-trihydroxyflavone
  • Chrysosplel D
  • 5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone
  • 7-Methylaxillarin
  • Quercetagetin 3,6,7-triMethyl ether
  • 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
  • 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-
  • cancer,Apoptosis,inhibit,ERK1/2,Inhibitor,antitrypanosomal,breast,Chrysosplenol D,anti-inflammatory
  • 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one
  • Chrysosplenol D, 10 mM in DMSO
  • 14965-20-9