2',4,4',6'-TETRAHYDROXYCHALCONE

Product Name: 2',4,4',6'-TETRAHYDROXYCHALCONE
CAS No.: 25515-46-2
Chemical Name: 2',4,4',6'-TETRAHYDROXYCHALCONE
Synonyms: Naringenin chalcon;cNaringenin chalcone;Naringenin chalcone-RM;2',4,4',6'-TETRAHYDROXYCHALCONE;1-(2,4,6-Trihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one;(E)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)-
CBNumber: CB81407576
Molecular Formula: C15H12O5
Formula Weight: 272.25
MOL File: 25515-46-2.mol

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2',4,4',6'-TETRAHYDROXYCHALCONE Property

Boiling point:: 538.7±50.0 °C(Predicted)
Density: 1.483±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 6.94±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83877
Product name: Naringenin chalcon
Purity: phyproof Reference Substance
Packaging: 10mg
Price: $580
Updated: 2025/07/31

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2',4,4',6'-TETRAHYDROXYCHALCONE Chemical Properties,Usage,Production

Uses

food and beverages

Definition

ChEBI: 2',4,4',6'-tetrahydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. It has a role as a metabolite, an anti-allergic agent and an anti-inflammatory agent. It is a polyphenol and a member of chalcones. It is functionally related to a trans-chalcone.

in vivo

(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice^[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice^[3].

Animal Model:	Mouse type I allergic model^[1]
Dosage:	0.8 mg/kg
Administration:	Oral administration
Result:	Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.

Animal Model:	Allergic airway inflammation induced in mice^[3]
Dosage:	0.8 mg/kg
Administration:	Oral administration, daily
Result:	Decreased cell numbers of the infiltrating leukocyte and eosinophils. Decreased Muc5ac and gob-5 expression in the lungs.

2',4,4',6'-TETRAHYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2',4,4',6'-TETRAHYDROXYCHALCONE Suppliers

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25515-46-2, 2',4,4',6'-TETRAHYDROXYCHALCONERelated Search:

Naringenin trimethyl ether Prunin Naringenin-4',7-diacetate

2',4,4',6'-TETRAHYDROXYCHALCONE

1-(2,4,6-Trihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one

Naringenin chalcon

2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)-

cNaringenin chalcone

(E)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one

Naringenin chalcone-RM

25515-46-2