Lincomycin hydrochloride

Antibiotic medicines Clinical application

Product Name: Lincomycin hydrochloride
CAS No.: 859-18-7
Chemical Name: Lincomycin hydrochloride
Synonyms: LINCOMYCIN HCL;Lincomycin hydrochloride monohydrate;Lincorex;Lintamycin;METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;Lizpion;U-10149A;Lincogap;Lincocin;Luniamycin
CBNumber: CB8141837
Molecular Formula: C18H35ClN2O6S
Formula Weight: 443
MOL File: 859-18-7.mol

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Lincomycin hydrochloride Property

Melting point:: 156-158C
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: solid
color: white to white with yellow cast
Water Solubility: Soluble in water.
BRN: 4171650
Stability:: Hygroscopic
InChI: InChI=1/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/s3
InChIKey: POUMFISTNHIPTI-BOMBIWCESA-N
SMILES: [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|
EPA Substance Registry System: D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36
WGK Germany: 2
RTECS: RH6315000
F: 10
HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L6004
Product name: Lincomycin hydrochloride
Purity: ≥90% (TLC)
Packaging: 1000000units
Price: $126
Updated: 2024/03/01

Sigma-Aldrich

Product number: L6004
Product name: Lincomycin hydrochloride
Purity: ≥90% (TLC)
Packaging: 5000000units
Price: $481
Updated: 2024/03/01

Sigma-Aldrich

Product number: L6004
Product name: Lincomycin hydrochloride
Purity: ≥90% (TLC)
Packaging: 25000000units
Price: $1220
Updated: 2024/03/01

Sigma-Aldrich

Product number: L2774
Product name: Lincomycin hydrochloride
Purity: BioReagent, suitable for cell culture
Packaging: 1000000units
Price: $74.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: L2774
Product name: Lincomycin hydrochloride
Purity: BioReagent, suitable for cell culture
Packaging: 5000000units
Price: $259
Updated: 2024/03/01

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Lincomycin hydrochloride Chemical Properties,Usage,Production

Antibiotic medicines

Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics. Through interaction with the 50S ribosomal subunit of the sensitive bacteria, it prevents the peptide chain elongation, thereby inhibiting protein synthesis of the bacterial cell with antimicrobial effect. However, at high concentrations, it also has bactericidal effect on the highly sensitive bacteria. Its antibacterial spectrum is the same as lincomycin but with a stronger antibacterial activity and can be subject to oral absorption quickly and completely (about 90%) with meal having little effect on the absorption. Lincomycin hydrochloride mainly has strong antibacterial effect against Gram-positive bacteria, and some anaerobic bacteria as well as Mycoplasma with its antibacterial spectrum narrower than erythromycin. Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumonia Mycoplasma hyopneumoniae, and Mycoplasma gallisepticum are sensitive to the chemicals, but enterococci is generally resistant to the chemicals; anaerobic bacteria such as Bacteroides spp., Clostridium tetani, Clostridium difficile, Clostridium perfringens and Peptococcus are also sensitive to the chemicals. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis. It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats.
Lincomycin hydrochloride has therapeutic effect when being used for the treatment of Sepsis, female genital tract, endometritis, non-gonococcal tubo-ovarian abscess, pelvic cellulitis; postoperative vaginal annex infections, peritonitis, abscesses, pneumonia, lung abscess, skin and soft tissue infections caused by most Gram-negative bacteria and some anaerobic bacteria. It can also be used for the surgical adjuvant treatment of Sepsis caused by streptococci and staphylococci, bone and joint infections, chronic bone and joint infections as well as the acute hematogenous osteomyelitis of Staphylococcus aureus. But this product can’t penetrate into cerebrospinal fluid and therefore not suitable for the treatment of meningitis. Topical administration can be applied for the treatment of Gram-positive bacteria purulent infection.

Clinical application

1. Oral formulations is suitable for treating respiratory infections, abdominal infection, female reproductive tract infections, pelvic infections, skin and soft tissue infections caused by sensitive Staphylococcus aureus and Streptococcus pneumoniae.
2. In addition to the treatment of the above infections, injected formulations are suitable for treatment of severe infections caused by streptococcus, pneumococcus and staphylococcus such as the surgical adjuvant therapy of septicemia, bone and joint infections, chronic bone and joint infections and Staphylococcus-induced acute hematogenous osteomyelitis.
3. Lincomycin hydrochloride may also be used for the treatment of infectious diseases in patients allergic to penicillin or not suitable for administration of penicillin-type drugs.
Tablets: Each tablet 0.25g, 0.5g; Injection: each 0.2g, 0.6g.
This information is edited by Xiongfeng Dai from Chemicalbook.

Chemical Properties

Crystalline

Originator

Lincocin,Upjohn,UK,1964

Uses

An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.

Uses

Antibacterial;Ribosomal protein synthesis inhibitor

Uses

Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Manufacturing Process

As described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.

brand name

Lincocin (Pharmacia & Upjohn).

Therapeutic Function

Antibacterial

General Description

Chemical structure: macrolide

Biochem/physiol Actions

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.? Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Clinical Use

Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.

Lincomycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lincomycin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lincomycin hydrochloride 859-18-7
Price: US $0.00/BOU/Drum
Min. Order: 1KG
Purity: 96%-102%;EP
Supply Ability: 1000KGS
Release date: 2021-07-02

HebeiShuoshengImportandExportco.,Ltd

Product: Lincomycin hydrochloride 859-18-7
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-07

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Lincomycin Hcl 859-18-7
Price: US $0.00/bou
Min. Order: 20bou
Purity: 96%~102%
Supply Ability: 10000bou
Release date: 2024-04-24

859-18-7, Lincomycin hydrochlorideRelated Search:

Methylparaben Methyl salicylate Methyl acrylate Topotecan hydrochloride METSULFURON METHYL Basic Violet 1 Thioacetic acid N-Vinyl-2-pyrrolidone Kresoxim-methyl Methanol PYRAZOPHOS Thioacetamide Clindamycin hydrochloride N-Methyl-2-pyrrolidone Sodium thiosulfate pentahydrate Pyrrolidine Tribenuron methyl Lincomycin

METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE

LINCOMYCIN HCL

LINCOMYCIN HYDROCHLORIDE

LINCOCIN HYDROCHLORIDE

lincomycin standard solution

ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE

U-10149A

N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE

D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride

lincomycin solution

D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-

D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride (9CI)

D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-a- (8CI)

Lincogap

LINCOMYCINHYDROCHLORIDEANHYDROUS

LINCOMYCIN CHLOROHYDRATE

Lincocin

Lincomycin hydrochloride BP98

Lincomycin hydrochloride monohydrate

Lincorex

Methyl (2S-trans)-6,8-dideoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride

LINCOMYCIN HYDROCHLORIDE CELL CULTURE*TE STED

Linocin, NSC 70731, U 10149a

methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside,hydrochloride (1:1)

Lincoymcin Hcl

Lincomycin hydrochloride (Lincocin)

Lineomycin Hydrochloride

Lincomycin (U-10149A)

Lincomycin Hydrochloride CAS 859-18-7

D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride

Lincomycin hydrochloride Solution, 100ppm

Lincomycin hydrochloride Solution, 1000ppm

LINCOMYCIN HYDROCHLORIDE >= 95.0% (T

Lincomycin Hydrochloride Bp/Ep

LINOCOMYCIN HYDROCHLORIDE

(2S,E)-Methyl-6,8-didezoxy-6(1-methyl-4-propylpirrolidine-yl-carbonylamino)-1-thio-D-eritro-a-D-halaktooktopiranoziide, hydrochloride monohydrate

Lyncomycin,HCl

Lincocin hydrocheoride

Lintamycin

Lizpion

Luniamycin

Pelancocin

Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

(2S,4R)-N-{(1S)-2-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-2-pyranyl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride

(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-Methyl-4-propyl-2-pyrrolidinyl)carbonyl] aMino]-1-thio-D3-threo-α-D-galactooctopyranoside Hydrochloride

LincoMycin hydrochloride (U-10149A)

Lincomycin hydrochloride,Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

Lincomycin hydrochloride 90%

incomycin hydrochL

Lincomycin hydrochloride Solution in Methanol, 100μg/mL

(2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride

Lincomycin hydrochloride USP/EP/BP

Lincocin Hcl

(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]

Lincomycin HCI

Lincomycin HydrochlorideQ: What is Lincomycin Hydrochloride Q: What is the CAS Number of Lincomycin Hydrochloride Q: What is the storage condition of Lincomycin Hydrochloride Q: What are the applications of Lincomycin Hydrochloride