MAHANINE

Product Name: MAHANINE
CAS No.: 28360-49-8
Chemical Name: MAHANINE
Synonyms: MAHANINE;(-)-Mahanin;(3R)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazol-9-ol;Pyrano[3,2-a]carbazol-9-ol, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3R)-
CBNumber: CB81421484
Molecular Formula: C23H25NO2
Formula Weight: 347.45
MOL File: 28360-49-8.mol

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MAHANINE Property

Melting point:: 100-loC
Boiling point:: 548.0±50.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
pka: 10.11±0.40(Predicted)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN92199
Product name: Mahanine
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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MAHANINE Chemical Properties,Usage,Production

Description

This terpene alkaloid, also occurring in the leaves of Murraya koenigii Spreng., is laevorotatory, having [α]_D - 24.4°. Two methyl groups, one phenolic hydroxyl, an imino group and an unsaturated side chain are present.

Uses

Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

in vivo

Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmaniainfection^[1].

Animal Model:	Balb/c mice with virulent AG83 promastigotes^[1]
Dosage:	20?mg/kg-40 mg/kg
Administration:	oral gavage; 20?mg/kg/40 mg/kg; b.w/day; 5 days
Result:	Had the potential to clear parasite burden?in vivo.Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T?cell proliferation in vivo.

IC 50

Leishmania

References

Narasimhan, Paradkar, Kelkar.,lnd. J. Chem., 8,473 (1970)

MAHANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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MAHANINE Suppliers

China 40 India 1 United States 2 Global 43

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71829
Advantage: 60

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 8914
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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Email: 3007523370@qq.com
Country: China
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30231
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Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
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Shanghai Hongshun Biological Technology Co., Ltd.

Tel: 15901914505 15901914505
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Email: 3187892335@qq.com
Country: China
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BioBioPha Co., Ltd.

Tel: 0871-65217109
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 1388
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28360-49-8, MAHANINERelated Search:

MAHANINE

(-)-Mahanin

(3R)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazol-9-ol

Pyrano[3,2-a]carbazol-9-ol, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3R)-

28360-49-8