ChemicalBook > CAS DataBase List > 4-CYANO-PYRIDINE-2-METHANOL

4-CYANO-PYRIDINE-2-METHANOL

Product Name: 4-CYANO-PYRIDINE-2-METHANOL
CAS No.: 51454-63-8
Chemical Name: 4-CYANO-PYRIDINE-2-METHANOL
Synonyms: 4-CYNO-PYRIDINE-2-METHANOL;4-CYANO-PYRIDINE-2-METHANOL;4-Cyano-2-(hydroxymethyl)pyridine;2-HYDROXYMETHYL-ISONICOTINONITRILE;2-(hydroxymethyl)pyridine-4-carbonitrile;2-(hydroxyMethyl)-4-Pyridinecarbonitrile;2-(Hydroxymethyl)-pyridin-4-carbonitrile;4-Pyridinecarbonitrile, 2-(hydroxymethyl)-;4-CYANO-PYRIDINE-2-METHANOL ISO 9001：2015 REACH;2-(hydroxymethyl)pyridine-4-carbonitrile - [H86871]
CBNumber: CB8143806
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 51454-63-8.mol

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4-CYANO-PYRIDINE-2-METHANOL Property

Boiling point:: 282.4±25.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.06±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H633095
Product name: 2-(Hydroxymethyl)isonicotinonitrile
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Y9284
Product name: 2-(Hydroxymethyl)pyridine-4-carbonitrile
Packaging: 1g
Price: $297
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0011644
Product name: 4-CYANO-PYRIDINE-2-METHANOL
Purity: 95.00%
Packaging: 1G
Price: $975.45
Updated: 2021/12/16

AK Scientific

Product number: Y9284
Product name: 2-(Hydroxymethyl)pyridine-4-carbonitrile
Packaging: 10g
Price: $1127
Updated: 2021/12/16

Chemenu

Product number: CM132409
Product name: 2-(hydroxymethyl)isonicotinonitrile
Purity: 95%
Packaging: 5g
Price: $718
Updated: 2021/12/16

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4-CYANO-PYRIDINE-2-METHANOL Chemical Properties,Usage,Production

Synthesis

100-48-1

67-56-1

51454-63-8

Sulfuric acid (1.5 mL) was slowly added to a methanol (225 mL) solution of 4-cyanopyridine (15.7 g, 151 mmol) at room temperature, followed by heating and refluxing the mixture for 30 minutes. A solution of ammonium persulfate (54.9 g, 241 mmol) in water (100 mL) was added dropwise over 30 minutes under continuous reflux. After addition, the reaction was continued with stirring and reflux for 1 hour. Upon completion of the reaction, the solution was cooled to room temperature and the precipitate was collected by filtration. The filtrate was concentrated under reduced pressure to remove methanol. The pH was adjusted to 9 by adding saturated aqueous potassium carbonate to the residue and the precipitate was collected by filtration again. The filtrate was extracted with chloroform (100 mL × 4), the organic phases were combined and dried over anhydrous sodium sulfate. After the solvent was removed by evaporation under reduced pressure, the crude product was further purified by silica gel column chromatography (eluent: chloroform/methanol), and 2-(hydroxymethyl)isonicotinonitrile (7.95 g, yield 39%, off-white solid) was finally obtained.

References

[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 41, p. 6239 - 6245
[2] Patent: WO2008/8398, 2008, A2. Location in patent: Page/Page column 356
[3] Patent: WO2006/57860, 2006, A1. Location in patent: Page/Page column 136
[4] Tetrahedron, 1985, vol. 41, # 3, p. 617 - 620
[5] Patent: EP2816023, 2014, A1. Location in patent: Paragraph 0406

4-CYANO-PYRIDINE-2-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CYANO-PYRIDINE-2-METHANOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-CYANO-PYRIDINE-2-METHANOL 51454-63-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

51454-63-8, 4-CYANO-PYRIDINE-2-METHANOLRelated Search:

4-Pyridinecarbonitrile,2-(1-hydroxyethyl)- ethyl 4-cyano-2-pyridinecarboxylate 4-CYANO-PYRIDINE-2-METHANOL 4-cyano-2-pyridinecarboxylic acid

2-(hydroxymethyl)pyridine-4-carbonitrile

4-CYANO-PYRIDINE-2-METHANOL

2-HYDROXYMETHYL-ISONICOTINONITRILE

4-CYNO-PYRIDINE-2-METHANOL

4-Cyano-2-(hydroxymethyl)pyridine

2-(hydroxyMethyl)-4-Pyridinecarbonitrile

4-Pyridinecarbonitrile, 2-(hydroxymethyl)-

4-CYANO-PYRIDINE-2-METHANOL ISO 9001：2015 REACH

2-(Hydroxymethyl)-pyridin-4-carbonitrile

2-(hydroxymethyl)pyridine-4-carbonitrile - [H86871]

51454-63-8